NUTRITIONAL ETIOLOGY OF PREDIABETTIC AUTOIMMUNITY

青少年糖尿病自身免疫研究（DAISY）对567名具有IDDM中度和高度遗传风险的新生儿进行了从婴儿期到幼儿期的自身免疫发展跟踪研究。将收集婴儿在3、6、9、12和15个月时的饮食数据。在2岁、3岁、4岁、5岁和6岁时，建议收集幼儿饮食数据。将在9个月、15个月、2、3、4、5和6岁时从队列中采集血液样本。主要结果，针对特定胰岛细胞自身抗原的自身抗体，将在这些时间点进行分析。在567人的整个队列中，将检查饮食中抗氧化剂摄入在β细胞自身免疫（BCA）风险中的作用。将进行一项230人的病例队列研究（55名BCA患儿和175名无BCA患儿，其中测量血浆抗氧化剂水平）。主要的研究问题将集中在抗氧化剂摄入和血浆抗氧化剂的哪些成分（或成分组合）、剂量或时间与糖尿病相关自身抗体的出现和缓解有关。

A cohort of 567 newborns at moderate and high genetic risk for IDDM, is being followed through infancy and early childhood for the development of autoimmunity by the Diabetes Autoimmunity Study in the Young (DAISY). Data will be collected on the infant diet at 3, 6, 9, 12, and 15 months of age. At the ages of 2, 3, 4, 5, and 6 years it is proposed to collect early childhood diet data. Blood samples will be collected from the cohort at the ages of 9 months, 15 months, 2, 3, 4, 5, and 6 years. The primary outcome, autoantibodies to specific islet-cell autoantigens, will be analyzed at these time points. The role of dietary intake of anti-oxidants in the risk of beta-cell autoimmunity (BCA) using the whole cohort of 567 individuals will be examined. A case-cohort study of 230 individuals (55 children with BCA and 175 children without BCA, in which plasma levels of anti-oxidants are measured) will be conducted. The primary research questions will focus on what components (or combination of components), dose or timing of anti-oxidant intake and plasma anti-oxidants are associated with the appearance and remission of diabetes-related autoantibodies.