PLASMA CLEARANCE METHOD ESTIMATING GFR & ERPF

为了便于监测肾脏疾病的进展和评估临床疾病修饰治疗的影响，需要简化测量肾功能的方法。使用需要收集尿液的方法对患者来说通常是繁琐和困难的。因此，本研究的目的是验证单次注射对氨基马粪酸（PAH）和邻苯二甲酸盐的血浆清除方法，分别测量有效肾血浆流量（ERPF）和肾小球滤过率（GFR）。将对60名不同程度肾功能不全的志愿者进行评估。单次注射多环芳烃和碘甲酸酯后评估肾功能。将使用统计分析对结果进行比较，以确定血浆和肾脏清除率方法的精度、偏差和相关性。

Simplified methods of measuring kidney function are needed in order to facilitate monitoring of kidney disease progression and to assess the impact of disease modifying therapy in the clinic. Use of methods which require urine collection are often tedious and difficult for the patient to execute. Therefore, the objective of this study is to validate a single- injection plasma clearance method of para-aminohippurate (PAH) and iothalmate to measure effective renal plasma flow (ERPF) and glomerular filtration rate (GFR), respectively. Sixty volunteers with various degrees of renal insufficiency will be evaluated. Renal function will be evaluated following a single injection of PAH and iothalamate. The results will be compared using statistical analysis to determine the precision, bias and correlation of the plasma and renal clearance methods.