COCAINE, CAFFEINE AND NICOTINE--ORAL ABUSE AND BEHAVIOR

描述：(申请人摘要) 用大鼠进行的实验将确定药物剂量(可卡因，五氯苯酚， 咖啡因、咪达唑仑、己巴比妥、尼古丁) 胃内插管或静脉插管取决于饮用特定液体可以 建立一个喝醉的解决方案的口头偏好，无论它是(A) 药物溶液或(B)中性口味的溶液，以确定 口服药物偏好和滥用是否可以仅通过以下方式启动 药理学事件，一种尚未明确确立的关系。这个 随之而来的药理事件(如血清药物和代谢物水平) 对胃和静脉给药的描述，以及 灌胃和静脉注射药物强化阈值，以影响 药物强化的药代动力学-药效学模型 澄清可能在药物激动剂疗法的设计中被证明是有用的。这个 引发和维持口服药物的药理学事件 自我管理将被比作环境事件 (时间表诱导的多饮)，这也可能导致慢性口服药物 自治。药物自我给药的程度 随之而来的妥协时机行为将衡量行为毒性 急性和慢性吸毒的后果。时间，刺激控制， 及影响口服液复吸的药理学因素 系统将评估您的首选项。

DESCRIPTION: (Applicant's Abstract) Experiments with rats will determine whether drug doses (cocaine, PCP, caffeine, midazolam, hexobarbital, nicotine) that are delivered by either intragastric or IV cannula contingent upon drinking a specific fluid can institute an oral preference for the solution drunk, whether it is (a) a drug solution or (b) a neutral-flavored solution, in order to ascertain whether oral drug preferences and abuse can be initiated solely by pharmacological events, a relation not yet clearly established. The pharmacological events (e.g., serum drug and metabolite levels) consequent to gastric and IV drug delivery will be delineated, as well as the intragastric and IV drug reinforcement thresholds, to effect the pharmacokinetic-pharmacodynamic modeling of drug reinforcement, which clarification may prove useful in the design of drug agonist therapies. The pharmacological events initiating and sustaining oral drug self-administration will be compared to the environmental events (schedule-induced polydipsia) which also can give rise to chronic oral drug self-administration. The degree to which drug self-administration compromises ensuing timing behavior will measure the behaviorally toxic consequences of acute and chronic drug-taking. Temporal, stimulus control, and pharmacological factors affecting the relapse to oral cocaine solution preference will be evaluated.