Dissecting PTEN-regulated pathways in the genesis of melanoma

黑色素瘤是澳大利亚的一大健康问题。它是男性和女性的第三种最常见的癌症，对多产的寿命有不成比例的严重影响。PTEN磷酸酶是黑色素瘤最常见的失活靶点之一。PTEN的确切作用及其在黑色素瘤发生中的作用尚未得到彻底的研究。这项工作将突出潜在的新途径和分子，这些可能在黑色素瘤的发生和靶向治疗的合理方法中至关重要。

Melanoma is a major Australian health problem. It is the third most common cancer in men and women and has a disproportionately heavy impact on productive years of life. The PTEN phosphatase is one of the most common targets for inactivation in melanoma. The precise role of PTEN and its contribution to melanoma development have not been thoroughly explored. This work will highlight potentially novel pathways and molecules that are likely to be critical in the genesis of melanoma and to the rational approach to targeted therapy.