SELECTIVE MODULATION OF ESTROGEN METABOLIC PATHWAYS

雌激素已被认为与乳腺癌的发病率有关。这可能会 这是由于体内不同雌激素的分布和水平所致 是由它的新陈代谢通过其他途径控制的。国际间- 酶的表达和活性的个体差异 因此，参与这种新陈代谢可能会成为易感风险 乳腺癌的致病因素。因此，雌激素代谢的调节 有利地改变体内雌激素的分布和水平可以是 用作管理策略。这个项目将对这种能力进行调查。

Estrogen has been implicated in the incidence of breast cancer. This could be due to the profile and level of different estrogens in the body which are controled by its metabolism by alternative pathways. The inter- individual differences in the expression & activity of the enzymes involved in this metabolism can therefore act as susceptibility risk factor for breast cancer. Consequently, modulation of estrogen metabolism to favorably alter the profile & level of estrogens in the body can be used as a mgmt strategy. This project will investigate this ability.