AGING ON BONE MINERAL CONTENT OF FEMALE RHESUS MONKEY: OSTEOPOROSIS

摘要目的：探讨增龄对骨量的影响。 用双能X射线吸收法测量。结果，而 与年龄相关的骨丢失在人类中是公认的， 在非人类灵长类动物中，年龄对骨密度的影响并不是很大。我们有 之前无法证明与年龄有关的损失交叉 从分部来看。这可能是标准的结果。 实验室饮食，富含钙和维生素D，由 人类的标准。未来方向我们将评估与年龄有关的问题 骨量的骨骼变化和骨转换的标志 一群年长的雌性猴子，用来证明有没有 “与年龄相关的”骨质流失。骨质疏松症；骨密度；骨 实力资助老年医学组酌情基金

OBJECTIVE: To assess the effect of advancing age upon bone mass as measured by dual energy x-ray absorptiometry. RESULTS While age-related bone loss in humans is well established, the effect of advancing age upon bone density in non-human primates is not. We have previously been unable to demonstrate "age-related" loss cross sectionally. It is possible that this is the result of the standard laboratory chow diet which is very high in calcium and vitamin D by human standards. FUTURE DIRECTIONS We will assess age related skeletal changes in bone mass and markers of bone turnover in this cohort of older female monkeys to document the presence or absence of "age-related" bone loss. Keywords Osteoporosis, bone density, bone strength Funding Geriatrics section discretionary funds