T1R DISPERSION IMAGING OF 17O OPTIMIZATION W/ ERROR ANALYSIS

质子T1r色散成像作为一种很有前途的方法 测量和成像17O浓度。然而，谨慎地选择 脉冲序列参数是其正常运行的关键。在……里面 特别是，自旋锁定时间和自旋锁定功率的选择 对于最大限度地提高敏感性和特异性是至关重要的 17O。我们已经开始使用“误差传播”分析来 确定组织的最佳自旋锁定功率和时间 不同的松弛性质和17O浓度。结果是 我们的数学模型将在体外和体内得到验证 实验。

Proton T1r dispersion imaging holds great promise as a method of measuring and imaging 17O concentrations. However, careful choice of pulse sequence parameters is crucial to its proper operation. In particular, the choices of spin-locking times and spin-locking powers are of utmost importance in maximizing the sensitivity and specificity for 17O. We have begun to use a "propagation of error" analysis to determine the optimum spin-locking powers and times for tissues of varying relaxation properties and 17O concentrations. The results of our mathematical modelling will be verified with in vitro and in vivo experiments.