GAIT DYNAMICS & FUNCTIONAL ASSESSMENT OF CHRONIC DISEASE

初步工作表明，基于步态动力学的措施可能 协助慢性疾病的功能评估和 由此导致的残疾。大约有4900万美国人患有慢性病 残疾。这些残疾通常会影响身体功能和行动能力， 限制活动，降低独立性，降低生活质量。然而， 缺乏精确、定量和客观的功能衡量标准 可以在多个环境中使用(例如，在临床中)限制我们的 能够客观地监测疾病进展并评估 新的治疗干预措施。本申请的总体目标是 扩展我们的初步发现以评估步态动力学的测量 可用于慢性疾病的功能评估。因为步态动力学 可作为一项敏感的和临床相关的功能能力指标。 对干预试验的评估，可能有助于加强早期 对于慢性病的诊断，我们认为了解其 起源。因此，该项目的次要目标是量化 描述导致步态动态变化的因素。第三 该应用程序的目的是开发步态动力学的实用测量方法 这可以用来加强对慢性致残疾病的临床评估。 在这个项目中，我们将研究慢性疾病(即， 膝骨性关节炎、帕金森氏病、亨廷顿病和肌营养不良 侧索硬化症)、步态动力学和功能状态，并评估步态 动态变化随着疾病的进展和对治疗的反应 干预措施，包括锻炼和脑深部刺激。结果是 这项研究将为人类的生理和适应能力提供新的见解。 慢性疾病，不同治疗干预措施的疗效，并可能 为增强慢性阻塞性肺疾病患者的功能评价提供了一种新的方法。 残疾。

Preliminary work suggests that measures based on gait dynamics may be useful in assisting in the functional assessment of chronic disease and the resulting disability. Approximately forty nine million Americans have a chronic disability. These disabilities often affect physical function and mobility, limit activities, reduce independence, and decrease quality of life. However, the absence of precise, quantitative and objective measures of function that can be administered in multiple settings (e.g., in the clinic) limits our ability to objectively monitor disease progression and assess the efficacy of new therapeutic interventions. The overall goal of the present application is to extend our preliminary findings to evaluate how measures of gait dynamics may be used in functional assessment of chronic disease. Because gait dynamics may serve as a sensitive and clinically relevant index of functional ability in the evaluation of intervention trials and may be useful in augmenting early diagnosis of chronic disease, we believe it is critical to understand its origins. A secondary goal of this project, therefore, is to quantitatively characterize the factors that contribute to altered gait dynamics. The third objective of this application is to develop practical measures of gait dynamics that can be used to augment clinical assessment of chronic disabling disease. In this project, we will study the relationship between chronic disease (i.e., knee osteoarthritis, Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis), gait dynamics, and functional status and evaluate how gait dynamics change with disease progression and in response to therapeutic interventions, including exercise and deep brain stimulation. The results of the study will provide new insight into the physiology and adaptations of chronic disease, the efficacy of different therapeutic interventions, and may also provide a new method to augment functional assessment of chronic disability.