CHIMERA SOFTWARE DEVELOPMENT

Chimera是我们的下一代分子图形应用程序 其主要设计目标是可扩展性和易用性。奇美拉是 用带有C++扩展的Python编写，并使用普遍接受的 TK、OpenGL等规范。此外，Chimera还使用 本地开发的对象技术框架。奇美拉是 进行了重大检修，以提高可移植性和性能。 在大修期间，我们还实施了大约75%的 我们以前的建模系统MidasPlus提供的功能。一个 还实施了对Chimera的若干扩展。多面性 序列文件查看器(MSFViewer)和结构比对查看器 (AlignPlot)报告已增强，可通过嵌合体进行交互 选拔机制。两个新的扩展，ViewDock和HearDock，是 实现以显示和发音停靠结果，其中包括一组 候选人模特方向和他们的分数。最后，在一个 继使用MidasPlus实施的概念验证之后，我们 在使用Chimera实现协作的设计阶段。 Chimera的发展也激励了其他项目的实施 开发工具。例如，我们实现了一个程序，该程序采用 作为输入的C++库接口，并生成必要的代码 使该功能在Python中可用，这既是一个 Chimera的开发和命令语言。

Chimera is our next generation molecular graphics application whose main design goals are extensibility and ease of use. Chimera is being written in Python with C++ extensions and uses commonly accepted specifications such as Tk and OpenGL. In addition, Chimera also uses the locally developed Object Technology Framework. Chimera was significantly overhauled to improve portability and performance. During the overhaul period, we also implemented roughly 75% of the functionality offered by MidasPlus, our previous modeling system. A number of extensions to Chimera were also implemented. The Multiple Sequence File Viewer (MSFViewer) and structure alignment viewer (AlignPlot) report were augmented to interact through the Chimera selection mechanism. Two new extensions, ViewDock and HearDock, were implemented to display and sonify docking results, which include a set of candidate model orientations and their scores. Finally, in a follow-up to the proof-of-concept implemented using MidasPlus, we are in the design stages of implementing a collaboratory using Chimera. The development of Chimera also inspired the implementation of other development tools. For example, we implemented a program which takes as input a C++ library interface and generates the necessary code to make the functionality available in Python, which is the both a development and command language for Chimera.