ESTIMATING REGIONAL FLOWS BY EXTERNAL DETECTION OF INTRAVASCULAR MARKERS

传统上，区域流量的估计使用外部 通过渡越时间进行了检测示踪剂动力学 分析. 然而，在体内条件下，指示剂再循环 通常会干扰渡越时间分析。 这种限制可以是 通过使用模型分析残留曲线来克服， 真实地表示血管结构，并对 血管输入功能。 这种方法对时间敏感， 残差数据的分辨率、输入函数的离散度 和数据的噪声含量。 该项目的目标是 开发利用X射线估算区域流量的一般方法 CT、MRI、超声和PET示踪剂，并定义 这些方法。

Traditionally, estimation of regional flow using externally detected tracer kinetics has been performed by means of transit time analysis. However, under in vivo conditions, indicator recirculation usually interferes with transit time analysis. This limitation can be overcome by analyzing the residue curves using a model that realistically represents the vascular architecture, and modeling the vascular input function. This approach is sensitive to the temporal resolution of the residue data, the dispersion of the input function and the noise content of the data. The goal of this project is to develop general approaches for estimating regional flow using X-ray CT, MRI, ultrasonic and PET tracers and to define the limitations of these approaches.