HELICOBACTER INFECTION AND GROWTH OF CHILDREN

描述 儿童幽门螺杆菌感染的预后不佳 明白几项流行病学研究报告了 H. pylori感染和生长迟缓，提示干扰 在儿童发育的关键时期的营养过程。 这些研究在设计上是横断面的，不能明确时间 关系：感染是否会导致生长发育迟缓， 儿童期的营养问题使宿主更容易受到初始的 感染？这项研究将提供一个前瞻性的评价， 假设H.幽门螺杆菌感染导致儿童生长减缓， 特别是在少数民族和服务不足的人群中。360人的队列 在日托中心的1-3岁西班牙裔男女儿童 在哥伦比亚的卡利，H. ~（13）C尿素呼气法检测幽门螺杆菌感染 在基线时进行UBT测试，将随访2年以监测其生长情况 每月测量体重和身高H.幽门 将每3个月用UBT和粪便-H监测感染。幽门 每月进行抗原修复试验预计结果将确立 H.幽门螺杆菌感染和生长迟缓，必要的 为评价H.儿童幽门螺杆菌感染 健康和针对适当的预防战略。

DESCRIPTION The outcomes of Helicobacter pylori infection in children are not well understood. Several epidemiologic studies have reported an association between H. pylori infection and growth retardation, suggesting interference with the nutritional process at critical periods of childhood development. Those studies were cross-sectional in design and cannot clarify the temporal relationship: does infection lead to retarded growth and development or do nutritional problems in childhood make the host more vulnerable to initial infection? This study will provide a prospective evaluation of the hypothesis that H. pylori infection leads to diminished growth in children, especially in minorities and underserved populations. A cohort of 360 Hispanic children of both sexes, ages 1-3 years, attending day care centers in Cali, Colombia, and negative for H. pylori infection by 13C Urea Breath Test (UBT) at baseline, will be followed for 2 years to monitor their growth with monthly measurements of weight and height. The incidence of H. pylori infection will be monitored with UBT every 3 months and by stool-H. pylori antigen retrieval test every month. The results are expected to establish the temporality of H. pylori infection and growth retardation, essential information for evaluating the effects of H. pylori infection on children's health and targeting appropriate preventive strategies.