A phenomic and genomic approach to identifying pharmaceutical targets for the amelioration of hematopoietic deficit

老鼠和人类在基因和生理上是相似的，并受到许多相同疾病的困扰。通过将随机DNA突变引入生殖系，可以产生具有疾病相关特征的小鼠，从而能够随后识别与特定人类疾病过程有关的基因。该项目将利用尖端基因技术来发现调节体内�的产生的基因，S主要的凝血剂：血小板。这在临床和商业上具有特别重要的意义，因为血小板数量的减少是先天性和自身免疫疾病、病毒感染(例如艾滋病毒)和癌症化疗危及生命的结果。

Mice and humans are genetically and physiologically similar, and are afflicted by many of the same diseases. By introducing random DNA mutations into the germline, mice with diseaseassociated characteristics can be generated, allowing the subsequent identification of genes involved in particular human disease processes. This project will utilise cutting-edge genetic technologies to discover genes that regulate production of the body�s principal blood clotting agents: platelets. This is of particular clinical and commercial importance since a reduction in platelet numbers is the life-threatening result of congenital and autoimmune diseases, viral infections (e.g. HIV) and cancer chemotherapy.