CORE--MOUSE BREEDING AND TRANSGENIC ANIMAL FACILITY

小鼠育种/转基因核心将维持和繁殖近交系(C3H/母鸡、BALB/c、C57BL/6)、同源和各种转基因和敲除品系，供所有三个项目使用。该核心还将产生项目所需的任何新的转基因小鼠，并负责所有转基因筛选。核心将向核心C(病毒载体核心)提供感染MMTV的小鼠的牛奶，以分离MMTV。中心还将监测小鼠在乳腺肿瘤或淋巴瘤发展方面的健康状况。该核心还将为项目提供病毒注射方面的帮助。核心领导格伦·高顿博士将监督技术员芭芭拉·希尔兹。芭芭拉·希尔兹将每两个月向执行委员会提交一次关于核心状态的报告，并将在科学会议上向方案所有成员通报可能使用的新技术。

The Mouse Breeding/Transgenic Core will maintain and breed inbred (C3H/HeN, BALB/c, C57BL/6), congenic and various transgenic and knockout strains to be used by all three projects. The core will also generate any new transgenic mice needed by the projects and be responsible for all transgenic screening. The core will provide milk from MMTV-infected mice to Core C (Virus Vector Core) for the isolation of MMTV. The health of the mice with regard to the development of mammary gland tumors or lymphomas will also be monitored by the Core. The core will also provide help to the projects with virus injections. The Core Leader, Dr. Glen Gaulton, will oversee the technician, Barbara Shields. Barbara Shields will make bi-monthly reports to the Executive Committee about the status of the core and will inform all members of the Program at scientific meetings about new technologies that might be used.