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BINDING OF CHARGED PEPTIDES & PROTEINS TO LIPID BILAYERS

BINDING OF CHARGED PEPTIDES & PROTEINS TO LIPID BILAYERS
带电肽的结合
批准号：
6314220
负责人：
BARRY H HONIG
金额：
$4.36万
依托单位：
COLUMBIA UNIV NEW YORK MORNINGSIDE
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
项目状态：
已结题
起止时间：
2000-05-05 至 2002-04-30
来源：
https://reporter.nih.gov/project-details/6314220
关键词：
biological products biomedical resource computers proteins statistics /biometry technology /technique

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中文摘要
翻译
Thephysicalforcesthatdeterminethebindingofproteinstothe曲面 膜是一个具有中心生物学意义的问题，通过它 与信号转导通路的关系。我们正在使用连续体 与该小组合作研究这个问题的静电学 斯图尔特·麦克劳克林正在将结合亲和力作为一个函数进行测量 脂肪成分和盐分。这项工作是使用一种 Nir Ben-Tal编写的Delphi并行版本，并在 CM-5。
英文摘要
Thephysicalforcesthatdeterminethebindingofproteinstothe surface of membranes is a problem of central biological importance through its relationship to signal transduction pathways. We are using continuum electrostatics to study this problem in collaboration with the group of Stuart McLaughlin who is measuring binding affinities as a function of lipid composition and salt. This work has been carried out using a parallel version of DelPhi written by Nir Ben-Tal and implemented on the CM-5.
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Structure-informed dissection of cancer-specific intracellular and paracrine networks
Genome-wide structure-based analysis of protein-protein interactions and networks
Genome-wide structure-based analysis of protein-protein interactions and networks
Genome-wide structure-based analysis of protein-protein interactions and networks
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