CARDIOVASCULAR RESPONSES TO PARTICULATE AIR POLLUTION

描述：(改编自《调查者摘要》)本研究的目的 是为了评估空气污染与心血管疾病的关系 疾病，特别是评估参数，可能有助于阐明 空气污染可能导致心血管疾病的生物机制 疾病。具体地说，这项研究将调查 暴露于标准空气污染物和心脏自主神经控制，由 心率变异性、心血管反应性、炎症标志物和 心律失常的存在。该项目还将调查两者之间的关系 环境空气污染和经证实的心血管疾病之间的关系，包括 心脏性猝死、心肌梗死、冠心病和中风。空气污染数据 将从美国环保局获得，并抽象为1、2、3或6天平均值 个人参与者之前日期的暴露水平=S临床 ARIC研究的基线和考试4的考试。ARIC的研究是一项双重标准的研究 对4个国家15,792人的心血管疾病进行基于人群的研究 美国社区。队列的基线检查发生在1987-1989年间， 每三年进行一次复查和复查。无数的生物 在这些访问中获得了措施和健康数据。

DESCRIPTION: (Adapted from the Investigator's Abstract) The aims of this study are to evaluate the relationship between air pollution and cardiovascular diseases and specifically to evaluate parameters which may help to elucidate biologic mechanisms by which air pollution may result in cardiovascular disease. Specifically, the study will investigate the relationship between exposure to criteria air pollutants and cardiac autonomic control measured by heart rate variability, cardiovascular reactivity, markers of inflammation and the presence of arrhythmias. The project will also investigate the relationship between ambient air pollution and validated cardiovascular disease including sudden cardiac death, myocardial infarction, CHD and stroke. Air pollution data will be obtained from the US EPA and abstracted into 1, 2, 3 or 6 day mean exposure levels for the dates prior to the individual participant=s clinical exams for baseline and exam 4 of the ARIC study. The ARIC study is a biracial population-based study of cardiovascular disease in 15,792 individuals in four US communities. The baseline examination of the cohort occurred from 1987-1989, with annual recontacts and reexaminations every three years. Numerous biologic measures and health data are obtained at these visits.