CARDIOVASCULAR RESPONSES TO PARTICULATE AIR POLLUTION

微粒空气污染的心血管反应

• 批准号: 6518163
• 负责人: Duanping Liao
• 金额: $ 17.83万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-01 至 2004-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6518163
• 关键词: air pollution; autonomic nervous system; cardiovascular disorder; cardiovascular disorder epidemiology; cardiovascular function; cardiovascular pharmacology; clinical research; environmental toxicology; human data; longitudinal human study

DESCRIPTION: (Adapted from the Investigator's Abstract) The aims of this study are to evaluate the relationship between air pollution and cardiovascular diseases and specifically to evaluate parameters which may help to elucidate biologic mechanisms by which air pollution may result in cardiovascular disease. Specifically, the study will investigate the relationship between exposure to criteria air pollutants and cardiac autonomic control measured by heart rate variability, cardiovascular reactivity, markers of inflammation and the presence of arrhythmias. The project will also investigate the relationship between ambient air pollution and validated cardiovascular disease including sudden cardiac death, myocardial infarction, CHD and stroke. Air pollution data will be obtained from the US EPA and abstracted into 1, 2, 3 or 6 day mean exposure levels for the dates prior to the individual participant=s clinical exams for baseline and exam 4 of the ARIC study. The ARIC study is a biracial population-based study of cardiovascular disease in 15,792 individuals in four US communities. The baseline examination of the cohort occurred from 1987-1989, with annual recontacts and reexaminations every three years. Numerous biologic measures and health data are obtained at these visits.

描述：（改编自研究者摘要）本研究的目的 评估空气污染和心血管疾病之间的关系， 疾病，特别是评估可能有助于阐明 空气污染可能导致心血管疾病的生物机制 疾病具体而言，该研究将调查 暴露于标准空气污染物和心脏自主控制测量 心率变异性、心血管反应性、炎症标志物和 心律失常的存在。该项目还将调查 环境空气污染和心血管疾病之间的关系， 心源性猝死、心肌梗死、CHD和中风。空气污染数据 将从美国环保署获得，并提取为1、2、3或6天平均值 个体受试者临床试验前日期的暴露水平 ARIC研究的基线检查和检查4。ARIC的研究是一个双向的 一项基于人群的心血管疾病研究，在四个国家的15，792名患者中进行 美国社区。队列的基线检查发生在1987-1989年， 每年重新接触，每三年复查一次。许多生物 在这些访问中获得测量和健康数据。

项目成果

Immunological responses of mice following administration of natural rubber latex proteins by different routes of exposure.

通过不同的暴露途径给予天然橡胶乳胶蛋白后小鼠的免疫反应。

• DOI: 10.1093/toxsci/55.2.343
• 发表时间: 2000
• 期刊: Toxicological sciences : an official journal of the Society of Toxicology
• 作者: Woolhiser,MR;Munson,AE;Meade,BJ
• 通讯作者: Meade,BJ

Determination of serum IgG antibodies to Bacillus anthracis protective antigen in environmental sampling workers using a fluorescent covalent microsphere immunoassay.

使用荧光共价微球免疫分析法测定环境采样人员中炭疽杆菌保护性抗原的血清 IgG 抗体。

• DOI: 10.1136/oem.2003.008565
• 发表时间: 2004
• 期刊: Occupational and environmental medicine.
• 作者: Biagini,RE;Sammons,DL;Smith,JP;Page,EH;Snawder,JE;Striley,CAF;MacKenzie,BA
• 通讯作者: MacKenzie,BA

Allergen concentration in natural rubber latex.

天然胶乳中的过敏原浓度。

• DOI: 10.1111/j.1365-2222.2006.02531.x
• 发表时间: 2006
• 期刊: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
• 作者: Yeang,H-Y;Hamilton,RG;Bernstein,DI;Arif,SAM;Chow,K-S;Loke,Y-H;Raulf-Heimsoth,M;Wagner,S;Breiteneder,H;Biagini,RE
• 通讯作者: Biagini,RE