CLINICAL & SEROLOGIC PREDICTORS OF NEUROPSYCHIATRIC SLE

据估计，高达75%的系统性红斑狼疮（SLE）患者在病程的某个阶段会出现某种类型的神经系统表现。最常见的包括中风、认知功能障碍和精神疾病，尽管还没有全面的特征。这项为期5年的系统性红斑狼疮患者神经系统疾病的前瞻性研究，其目标是对不同种族但以墨西哥裔美国人为主的系统性红斑狼疮患者的神经系统受累谱进行表征，并定义可能是特异性靶向神经系统表现的独特重要危险因素。该研究的假设之一是，在aPL和抗apoh抗体水平持续异常的SLE患者中，血栓闭塞事件的风险更高，并且认知功能障碍的发展将与这些抗体的血清水平异常暂时相关。

It has been estimated that up to 75% of patients with Systemic Lupus Erythematosus (SLE) experience some type of nervous system manifestations at some point in their disease course. The most common include stroke, cognitive dysfunction and psychiatric disease, although the full range has not been characterized. This five year, prospective study of nervous system disease in SLE patients has as its objectives the characterization of the spectrum of nervous system involvement in an ethnically diverse but predominately Mexican-American population of patients with SLE and the definition of important risk factors which may be unique for specifically targeted nervous system manifestations. Among the study's hypotheses is that the risk of thrombo-occlusive events will be higher in SLE patients who have persistently abnormal levels of aPL and anti-apoH antibodies and that the development of cognitive dysfunction will be temporally associated with abnormal serum levels of these antibodies.