TRAINING IN MOLECULAR PATHOGENESIS OF MICROBIAL DISEASES

描述(改编自应用程序)：建议的主要目标 培养计划是为研究生和博士后提供 一流的培训经验，为竞争激烈的职业生涯做准备， 科学研究中的独立调查人员，特别是在生物医学方面 机构。作为这一目标的一部分，我们将招聘有才华和上进心的人。 致力于生物医学研究的学生和研究员。该计划 将侧重于致病分子机制方面的培训， 了解宿主-微生物的相互作用，以及如何使用新的科学 基因组学和生物信息学的文化。这一地区需要新的科学家 因为感染性疾病仍然是最常见的 在发展中国家经常导致死亡的原因，并且仍然造成重大 发展中国家的发病率和死亡率。未来的成功之路 识别、预防和治疗新发或死灰复燃的传染病 通常具有抗生素抗药性的试剂将需要复杂的 对发病的分子基础和分子生物学的认识 致病微生物的数量。本培训计划由个人指导 研究顾问和总体上由一个项目治理委员会提供 衡量项目的成功程度。分子发病机制培训 包括实验室研究、每周系列研讨会、务虚会和进修班 发展良好的课程。这个项目提供一个多学科的研究 环境除了分子发病机制方面的正式指导外， 生物化学、遗传学、微生物学等领域。培训计划 拟招收5名博士后和5名博士后实习生， 医学博士和药物过量水平。学员经常接触到不同领域的 细菌(淋球菌、专性厌氧菌、假单胞菌、 螺旋体、葡萄球菌和链球菌)、病毒(巨细胞病毒、 肝炎和疱疹病毒)，真菌(隐球菌和肺孢子虫)，以及 原生动物(阿米巴和锥虫)病原体使用全方位的现代 分子技术。这项提议得益于一位 VCU-MCV跨学科研究生课程。

DESCRIPTION (adapted from the application): The major goal of this proposed training program is to provide graduate students and postdoctoral fellow with a first-rate training experience as preparation for careers as competitive, independent investigators in scientific research, particularly at biomedical institutions. As part of this goal, we will recruit talented and motivated students and fellows that are dedicated to biomedical research. The program will focus on training in molecular mechanisms of pathogenesis, in understanding host-microbe interactions, and in how to use the new scientific culture of genomics and bioinformatics. New scientists are needed in the area of molecular pathogenesis because infectious diseases are still the most frequent cause of death in the developing world and still cause significant morbidity and mortality in developing countries. Future success in the identification prevention, and treatment of new or resurgent infectious agents, that are often antibiotic resistant, will require sophisticated understanding of the molecular basis of pathogenesis and the molecular biology of pathogenic microbes. This training program is directed individually by research advisors and overall by a program governance committee that will measure the success of the program. Training in molecular pathogenesis includes laboratory research, weekly seminar series, retreats and advanced well-developed courses. This program provides a multidisciplinary research environment in addition to formal instruction in molecular pathogenesis, biochemistry, genetics, microbiology and other fields. The training program proposed is for five predoctoral and five postdoctoral trainees at the Ph.D., M.D., and D.O. levels. Trainees are regularly exposed to diverse areas of research on bacterial (gonococci, obligate anaerobes, pseudomonads, spirochaetes, staphylococci and streptococci), viral (cytomegalovirus, hepatitis, and herpesvirus), fungal (Cryptococcus and Pneumocystis), and protozoan (amebae and trypanosomes) pathogens using the full range of modern molecular techniques. The proposal benefits from the presence of an interdisciplinary graduate program at VCU-MCV.