TRAINING PROGRAM IN MOLECULAR BASIS OF AGING

描述：UTHSCSA要求提供五年的持续支持，以便每年在衰老的分子和细胞生物学领域为六名博士前和六名博士后学员提供深入培训。学员将参与涉及多个领域的项目，包括基因表达的程序性变化；基因表达的体细胞突变和表观遗传学变化；自由基、DNA损伤和DNA修复；内分泌和免疫系统的衰老；跨膜信号；细胞生长、分化和凋亡中的癌基因和肿瘤抑制基因；以及与年龄相关的疾病的分子方面，如阿尔茨海默病、帕金森氏病、前列腺增生和视网膜退化。发育和衰老的分子生物学课程和关于老年学当前主题的期刊俱乐部将继续作为教学培训的正式场所。老龄化研讨会系列将是受训者与从事发育和衰老调节生物学工作的著名科学家互动的焦点。一个新的特点是成立了一个外部咨询委员会，由著名的老年学家和分子生物学家组成，他们将评估受训人员的进展情况，并就影响培训方向的事项向培训主任提供建议。学员将根据学业成绩和推荐信中反映的学术成就和对研究、教学和服务行业的职业动机进行挑选。将进行广泛的尝试，以确定对老龄领域真正感兴趣的受训人员。

DESCRIPTION: Five years of continuing support are requested by UTHSCSA to provide in-depth training to six predoctoral and six postdoctoral trainees annually in the area of the molecular and cellular biology of aging. Trainees will participate in projects involving many areas, including programmed changes in gene expression; somatic mutations and epigenetic changes in gene expression; free radicals, DNA damage and DNA repair; aging of endocrine and immune systems; transmembrane signaling; oncogenes and tumor suppressor genes in cell growth differentiation and apoptosis; and the molecular aspects of age-associated diseases such as Alzheimer's disease, Parkinson's disease, prostatic hyperplasia and retinal degeneration. The Molecular Biology of Development and Aging course and journal clubs on current topics in gerontology will remain as the formal setting for didactic training. The Aging Seminar Series will be the focal point of interactions of the trainees with eminent scientists working on the regulatory biology of development and aging. A new feature is the formation of an external advisory committee, comprised of noted gerontologists and molecular biologists, who will evaluate trainee progress and advise the training director on matters affecting training direction. Trainees will be selected based on academic excellence and motivation for careers in research, instruction and service as reflected from their academic records and letters of recommendation. Extensive attempts will be made to identify trainees with genuine interest in the field of aging.