PROSPECTIVE STUDY OF CHILDREN OF SCHIZOPHRENIC PARENTS

这是纽约高中主要数据收集的最后阶段- 风险项目(NYHRP)，一个多特征、多测量、前瞻性的项目 研究中，两个独立的子代样本 精神分裂症、情感疾病和正常父母的跟踪调查 从7岁到12岁开始反复测试和临床评估 1971-72年或77-79年。最初的目标是及早发现 精神分裂症的神经生物学预测因子。这一目标已经扩展为 该领域已经发展到专注于定义完整的 内表型和临床性状的表型互补 精神分裂症的发病率更高。虽然我们会收集最新的 临床、环境和家族病史数据在这一阶段，我们将 主要集中在对积累的数据进行评级和综合 先前并集成不同的变量域(例如， 社会和神经行为测量)在广泛的分析中 将需要解决本文件中提出的问题和假设 纵向研究。具体地说，我们将1)从我们广泛的 档案，积累的社会、环境和心理数据 大约350个后代和他们最近的大约160个 检查兄弟姐妹；2)准备后代的生命档案，使用 所有数据来源；3)身体/精神的数组家族谱系 (包括Axis L的诊断和Axis Il特征) 父母、子女和二级亲属。我们会收集 附加数据包括：4)邮寄问卷，以获得“精神病-- 5)终轴I和 对较年轻的样本(样本B)的诊断性访谈和 选定样本A受试者；6)血液样本以保存DNA和 热休克蛋白在血清抗体检测中的应用 (HSP 60)；和z)继续每年电话采访 后代也更新他们自己的临床和治疗历史 因为他们有家族病史。我们还将：J8继续 为寻求帮助的受试者提供转介服务。最重要的是，我们 将进行大量的数据分析，重点放在：比较 特定性状作为遗传易感性的指标的潜力 精神分裂症和成年后精神疾病的预测因子； 这种分析将包括构建综合性状指数 以及兄弟姐妹和其他家系内比较的检查，如 上述家庭聚集性和分离性的估计 特征。

This is the final phase of major data collection in the New York High- Risk Project (NYHRP), a multi-trait, multi-measurement, prospective study, in which two independent samples of offspring of schizophrenic, affectively ill and normal parents have been followed with repeated testing and clinical evaluations since ages 7 to 12 in 1971-72 or '77-'79. The initial goal was to identify early neurobiological predictors of schizophrenia. This goal has expanded as the field has evolved to focus on the problem of defining the full phenotypic complement of endophenotypic and clinical traits making up the schizophrenia spectrum. Although we will collect updated clinical, environmental and family history data in this phase, we will concentrate chiefly on rating and synthesizing the data amassed previously and integrating the different domains of variables (e.g., social and neurobehavioral measures) in the extensive analyses that will be needed to resolve the questions and hypotheses posed in this longitudinal study. Specifically, we will 1) rate, from our extensive files, accumulated social, environmental and psychological data on the approximately 350 offspring and their approximately 160 recently examined siblings; 2) prepare lifetime profiles on the offspring, using all sources of data; 3) array family pedigrees of the physical/mental (including Axis l diagnoses and Axis Il features) health histories on the parents, offspring, and second-degree relatives. We will collect additional data with: 4) mailed questionnaires to obtain "psychosis- proneness" and schizotypy scales on the offspring; 5) final Axis I and II diagnostic interviews with the younger sample (Sample B) and selected Sample A subjects; 6) blood samples to preserve DNA and for use in an assessment of serum anti-bodies for the heat-shock protein (hsp 60); and Z) continued annual telephone interviews with the offspring to update their own clinical and treatment histories, as well as their family histories of disorders. We will also: J8 continue to offer referral services to subjects seeking assistance. Most of all, we will 9) conduct a large number of data analyses focused on: comparing the potential of specified traits as indicators of the genetic liability to schizophrenia and as predictors of adulthood psychiatric conditions; such analyses will include construction of composite indices of traits and examination of sib-pair and other intra-pedigree comparisons as estimates of familial aggregation and segregation of the aforementioned traits.