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PET STUDY OF CNS BENZODIAZEPINE RECEPTORS IN ADOLESCENT ONSET ALCOHOLISM

PET STUDY OF CNS BENZODIAZEPINE RECEPTORS IN ADOLESCENT ONSET ALCOHOLISM
青少年酒精中毒中枢神经系统苯二氮卓受体的 PET 研究
批准号：
6304692
负责人：
DUNCAN B. CLARK
金额：
$0.3万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-12-01 至 2000-11-30
来源：
https://reporter.nih.gov/project-details/6304692
关键词：
adolescence (12-20) alcoholic beverage consumption alcoholism /alcohol abuse benzodiazepine receptor central nervous system disorders clinical research human subject neurochemistry positron emission tomography receptor expression receptor sensitivity toxicant interaction toxicology

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中文摘要
翻译
这项研究建议使用PET显示的[11C]氟马西尼结合来获得慢性和酒精消费对青少年初发酒精依赖患者苯二氮卓类受体(BZR)分布和密度的影响的初步数据。长期饮酒引起的GABA神经递质系统的改变是酒精依赖的最可能的神经化学底物。与对照组相比，患有青春期酒精使用障碍的受试者将显示扣带皮质中[11C]-氟马西尼的结合减少。
英文摘要
This study proposes to obtain pilot data on the effects of chronic and alcohol consumption on benzodiazepine receptor (BZR) distribution and density in adolescent onset alcohol dependence using [11C] flumazenil binding visualized by PET. Alterations in the gamma-aminobutyric acid (GABA) neurotransmitter system induced by chronic alcohol consumption represent the mostly likely neurochemical substrate of alcohol dependence. Subjects with adolescent-onset alcohol use disorders, compared with controls, will show reduced binding of [11C]-flumazenil in the cingulate cortex.
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