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DEVELOPING AN ANIMAL MODEL FOR ATOPIC DERMATITIS

DEVELOPING AN ANIMAL MODEL FOR ATOPIC DERMATITIS
开发特应性皮炎动物模型
批准号：
6307330
负责人：
FU-TONG LIU
金额：
$2.74万
依托单位：
SCRIPPS RESEARCH INSTITUTE, THE
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-12-01 至 2001-02-28
来源：
https://reporter.nih.gov/project-details/6307330
关键词：
SCID mouse atopic dermatitis clinical research disease /disorder model helper T lymphocyte human subject model design /development

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中文摘要
翻译
本研究的目的是阐明Galectin-9在变态反应性炎症中的作用。Galectin-9是Galectin家族的成员之一，最近被发现是由T细胞产生的一种有效的嗜酸性粒细胞趋化剂。我们建议研究Galectin-9在过敏性炎症中的表达，以及该蛋白吸引嗜酸性粒细胞的能力。建议的目标包括：a)定量测定正常人或过敏性疾病患者白细胞中Galectin-9的水平；b)Galectin-9对嗜酸性粒细胞的趋化作用；c)定量鼻灌洗液中Galectin-9的水平，以响应过敏原的攻击。
英文摘要
This objective of this study is to elucidate the role of galectin-9 in allergic inflammation. Galectin-9 is a member of the galectin family recently shown to be a potent eosinophil chemoattractant produced by T cells. We propose to study the expression of galectin-9 in allergic inflammation and the ability this protein has to attract eosinophils. The proposed aims include a) quantitation of the level of galectin-9 in leukocytes from normal donors or patient swith allergic disease; b) chemoattractant of eosinophils by galectin-9 and c) quantitation of the levels of galectin-9 in nasal lavage fluid in response to allergen challenge.
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DEVELOPMENT OF NONHUMAN PRIMATE MODELS OF ATOPIC DERMATITIS
Galectin-3 in regulation of allergic skin inflammation
DEVELOPMENT OF NONHUMAN PRIMATE MODELS OF ATOPIC DERMATITIS
Galectin-3 in regulation of allergic skin inflammation
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