New Synthetic Approaches to Halogenated Medium Ring Ethers from Laurencia

自从20世纪60年代从Laurencia物种中分离出卤代中环醚以来，它引起了人们极大的关注。1，2我们最近提出并实验证实了这些结构复杂的分子的统一生物发生。3，4在这项工作中，我们采用了一种新的分子内环化方案。我们现在打算将这项工作扩展到一种更灵活的分子间官能化方法。通过这种方式，我们将以家庭中天然存在的氯溴中环醚为目标。该项目至少符合EPSRC的两个优先领域：催化和新型高效化学合成1。题名/责任者：The First of First：/by J.1965、16、1091-1099年。2.有关评论，请参阅：王宝荣；Gloer，J.B.；季羡林，纽约；赵俊正，化学。2013年版，第113页，第3632-36853页。题名/责任者：The First of the First.化学。2012、77、9574-9584和其中引用的参考文献。有关针对这一类的双环成员的更新工作，请参阅：Braddock，DC；SBircea，D.-T.Chem。交警。2014年，50,12691-12693.4。该方法的发展见：Bonney，K.J.；Braddock，D.C.；White，A.J.P.；Yaqoob，M.J.Org。化学。2011、76、97-104。

The halogenated medium ring ethers from Laurencia species have attracted much synthetic attention since the isolation of Laurencin in the 1960s.1,2 We have recently proposed and experimental corroborated a unifying biogenesis of these structurally complex molecules.3,4 In that work we employed a novel intramolecular cyclisation protocol. We now intend to extend this work to a more flexible intermolecular functionalization method. In this manner we will target the naturally occurring chlorobromide medium ring ethers of the family.The project fits with at least two EPSRC priority areas: Catalysis & Novel and Efficient Chemical Synthesis.1. Irie, T.; Suzuki, M.; Masamune, T. Tetrahedron Lett. 1965, 16, 1091-1099. 2. For a review see: Wang, B.-G.; Gloer, J. B.; Ji, N.-Y.; Zhao, J.-C. Chem. Rev. 2013, 113, 3632-36853. Bonney, K. J.; Braddock, D. C. J. Org. Chem. 2012, 77, 9574-9584 and references cited therein. For more recent work targeting bicyclic members of the class see: Braddock, D. C.; Sbircea, D.-T. Chem. Commun. 2014, 50, 12691-12693.4. For the development of the method see: Bonney, K. J.; Braddock, D. C.; White, A. J. P.; Yaqoob, M. J. Org. Chem. 2011, 76, 97-104.