Neural Circuitry of Social Behavior in Bonnet Macaques

描述（由申请人提供）：在试图了解社会行为的基本神经生物学，灵长类动物模型将是理想的。帽子猕猴（Macaca radiata）是一种表现出一系列复杂社会行为的非人类灵长类动物的特别好的例子。在这项提案中，我们提出了一个生物行为灵长类动物实验室和临床神经影像组之间的合作，探索，开发和实施的方法，将允许特定的神经生物学底物调节灵长类动物的社会行为方面的研究。首先，我们计划进行基线磁共振成像研究，包括体积分析，磁共振波谱分析和扩散张量成像，在24个帽子在发展的早期，以表征大脑结构和功能，这是反映在社会表现的配置文件。感兴趣的主要区域是纹状体，反映了该区域在调节大脑奖励途径中的作用的证据的收敛，这可能有助于灵长类动物的强化参与社会活动。其次，为了评估社会行为，我们将开发一系列社会互动的视频模拟，可用于测试帽子的可区分响应性，从而能够在受控和可量化的条件下研究社会行为。该研究的主要假设是，将有一个连续的纹状体病理之间的24个帽子测量的3种成像方式，和那些帽子谁显示最病理成像配置文件将显示较少的社会参与时，面对生活的社会互动时，比面对社会视频遭遇。如果得到证实，这表明异常的纹状体“活力”阻碍了灵长类动物的整体社会灵活性和社会互动的驱动力。该项目的第二个目的是开发一个教育和未来的研究组成部分，其中将包括研究学徒和研究生和本科生的机会，在社会神经科学相关的项目工作。最终，这些知识将有助于更好地理解与社会行为相关的生物行为过程，与精神分裂症，社交焦虑症，自闭症和涉及人际社会行为破坏的人格障碍等疾病相关。

DESCRIPTION (provided by applicant): In attempting to understand the fundamental neurobiology of social behavior, a primate animal model would be ideal. The bonnet macaque (Macaca radiata) is a particularly good example of a species of nonhuman primate that exhibits a range of sophisticated social behaviors. In this proposal, we propose a collaboration between a biobehavioral primatology laboratory and a clinical neuroimaging group to explore, develop, and implement methods that would allow for the study of specific neurobiological substrates modulating aspects of primate social behavior. First, we plan to conduct baseline magnetic resonance imaging studies, including volumetric analyses, magnetic resonance spectroscopy, and diffusion tensor imaging, in 24 bonnets early in development in order to characterize a profile of brain structure and function which is reflected in social performance. The major region of interest is the corpus striatum, reflecting a convergence of evidence of this region's role in modulating brain reward pathways, which might subserve a primate's reinforcement to engage in social activity. Second, to assess social behavior, we will develop a series of video simulations of social interactions that can be used to test bonnets' differentiable responsivity, enabling the study of social behavior under controlled and quantifiable conditions. The study's main hypotheses are that there will be a continuum of striatal pathology among the 24 bonnets as measured by the 3 imaging modalities, and those bonnets who display the most pathological imaging profiles will display less social engagement when confronted with live social interactions than when confronted with social video encounters. If confirmed, this suggests that abnormal striatal "viability" impedes a primate's overall social dexterity and drive for social interaction. A secondary aim of this project is to develop an educational and future research component, which will include a research apprenticeship and opportunities for graduate and undergraduate students to work in social neuroscience-related projects. Ultimately, this knowledge will contribute to a better understanding of the biobehavioral processes related to social behavior, with relevance to disorders such as schizophrenia, social anxiety disorder, autism, and personality disorders involving disruption of interpersonal social behavior.