ASSEMBLIES OF SELF COMPLEMENTARY STRUCTURES

本申请寻求对合成的研究的持续支持 分子组装。这些组件是可逆形成的二聚体 由自我互补的分子组成，并通过 分子间作用力较弱。这些组件将成为闭合外壳 包裹较小分子的结构。合成技术 在这些不同大小、形状和溶解度的胶囊中 以及他们的集会的行为有待确定。 需要解决的具体问题涉及功能 来宾绑定上的组；动态过程，如进入和 以及胶囊内的分子运动 使用胶囊作为反应室来催化 重排；胶囊的容量不对称 微环境，以及它们作为传感器或信号装置的用途。 在这些人造系统中观察到的许多现象 模仿自然发生的组件，如变构 酶和病毒外壳蛋白。人们希望，管理的规则 装配工艺和选型、 它们的存在归功于集合体的运输和催化作用， 可以用合成系统破译。

This application seeks continued support for studies of synthetic molecular assemblies. The assemblies are reversibly formed dimers of self-complementary molecules and are held together through weak intermolecular forces. The assemblies become closed-shell structures that act to encapsulate smaller molecules. The syntheses of these capsules of various sizes, shapes and solubilities are proposed and the behavior of their assemblies are to be determined. The specific issues to be addressed involve the effects of functional groups on guest binding; dynamic processes such as rates into and out of the capsules and molecular motions within the capsule by the guest; the use of the capsules as reaction chambers to catalyze rearrangements; the capacities of the capsules as asymmetric microenvironments, and their use as sensors or signaling devices. Many of the phenomena observed with these synthetic systems mimic those of naturally occurring assemblies such as allosteric enzymes and viral coat proteins. It is hoped that the rules governing the assembly process and the phenomena such as selection, transport and catalysis which owe their existence to the assembly, can be deciphered with the synthetic systems.