CRYSTALLOGRAPHIC ANALYSIS OF SESQUITERPENE CYCLASES

植物衍生的环状萜类化合物，包括衍生自 从香叶基二磷酸衍生的倍半萜类化合物， 二磷酸和衍生自香叶基香叶基二磷酸的二萜类化合物， 包括重要的一类次级代谢物， 植物与环境的相互作用。 从一个与健康有关的 从这个角度来看，这些化合物也代表了一类重要的 潜在的抗生素、抗真菌剂和抗肿瘤剂。 客观 我们的研究目的是尽可能全面地了解 结构、功能和化学特征决定了两种不同的 二磷酸法呢酯（FPP）的立体化学控制环化 由两种高度同源的植物萜烯环化酶催化， 产生两种独特的双环产物。

Plant derived cyclic terpenoids including monoterpenoids derived from geranyl diphosphate, sesquiterpenoids derived from farnesyl diphosphate and diterpenoids derived from geranylgeranyl diphosphate, comprise a significant class of secondary metabolites that mediate a plant's interaction with its environment. From a health related perspective, these compounds also represent an important class of potential antibiotic, antifungal and anti tumor agents. The objective of our research is to understand as completely as possible the structural, functional and chemical features governing two distinct stereochemically controlled cyclizations of farnesyl diphosphate (FPP) catalyzed by two highly homologous plant sesquiterpene cyclases that result in two unique bicyclic products.