PLASMA D CHIRO INOSITOL LEVELS PREDICT CIRCULATING TRIGLYCERIDES IN DIABETICS

人们对罕见的肌醇异构体D-甲氧基肌醇很感兴趣 被它在肌醇磷酸多糖分子中的发现所点燃 模拟胰岛素的某些肌动蛋白，包括体外对血脂的影响 新陈代谢。为了确定D-肌醇是否可能是 在糖尿病患者的临床脂代谢中的重要性 负离子气体法测定血浆D-甲酰肌醇浓度 色质联用，并与循环系统进行比较。 73名受试者的横断面研究中的脂蛋白和其他协变量 糖尿病患者和42名正常受试者。在一个由28人组成的小组中 糖化血红蛋白>的胰岛素缺乏型NIDDM患者 10%时，血浆D-甲环肌醇水平呈正相关 与血浆甘油三酯相关，是独立性最强的 观察血浆甘油三酯的预测因素。他们之间没有任何关系 血浆L-肌醇与血浆甘油三酯。电浆 在非糖尿病S受试者中，D-肌醇与血脂无关。 血浆D-肌醇和D-肌醇的密切统计关系 糖尿病患者的血浆甘油三酯水平表明 D-环肌醇代谢紊乱可能是糖尿病的一个组成部分 血脂异常。

Interest in the rare inositol isomer D-chiro-inositol has been kindled by its discovery in inositol phosphoglycan molecules which mimic certain actins of insulin including in vitro effects on lipid metabolism. In order to determine whether D-chiro-inositol might be important in clinical lipid metabolism in diabetic patients, we measured plasma levels of D-chiro-inositol by negative ion gas chromatography/mass spectrometry and compared them to circulating lipoproteins and other covariates in a cross-sectional study of 73 diabetics and 42 normal subjects. In a subgroup of 28 relatively insulin-deficient NIDDM subjects with glycohemoglobin greater than 10%, plasma D-chiro-inositol level was positively and linearly correlated with plasma triglycerides and was the strongest independent predictor of plasma triglycerides observed. There was no relation of plasma L-chiro-inositol to plasma triglycerides. Plasma D-chiro-inositol was not related to lipids in nondiabetic s ubjects. Theclose statistical association between plasma D-chiro-inositol and plasma triglyceride levels in diabetic subjects suggests that disordered D-chiro-inositol metabolism may be a component of diabetic dyslipidemia.