POSTDOCTORAL TRAINING IN CARDIOVASCULAR DISEASE

描述（申请人摘要）这是心血管疾病机制中的多学科培训计划的竞争性更新，其基于新的血管和肺病理生物学中心，其目标是吸引外科和心脏病学的受训者进入基础实验室研究。 该计划的基本原理是加强和确保基础和临床研究人员的发展，他们在与心血管疾病研究相关的主要领域拥有广泛的知识。 在培训期间获得的深入背景和经验旨在使研究员能够作为独立调查员开始职业生涯。 有一个明确的需要与外科和心脏病学的观点，进行这样的培训，临床程序和病人护理密切相关的先进的研究。 参与的教师来自医疗中心的多个部门。 许多参与的教师都有长期的协作互动以及良好的培训记录。 培训计划将包括在教师导师的实验室中进行的研究工作，选定的研究生课程，研究领域的教程，教学和正在进行的研讨会系列，以及咨询委员会的评估。 该计划包括27个实验室，分为四个单位：（1）血管生物学，专注于血管细胞对低氧血症或病毒感染的适应性反应，以及新型血管受体;（2）炎症- Immug Ut，将专注于组织损伤的炎症和血栓形成机制;（3）基因组学，将肥胖和糖尿病的新遗传原因作为主要研究领域;（4）基因组学，将肥胖和糖尿病的新遗传原因作为主要研究领域。和（4）心脏生物学，其成员将研究钙释放通道的耦合门控、心肌血流和代谢、心室力学和心肌细胞信号级联。 项目汇集在一起，共同关注正常血管壁中的细胞，在病理情况下浸润的细胞成分，如动脉粥样硬化，以及心肌。 学员将参与的研究项目涉及解剖这些细胞在维持血管稳态中的作用，以及它们参与血管病变形成和进展的病理事件。 我们的目标是利用外科和心脏病学学员的才能和热情，将他们的注意力引导到富有成效的长期研究事业中。

DESCRIPTION (Applicant's Abstract) This is a competing renewal for a multidisciplinary training program in mechanisms of cardiovascular disease, based in the new Center for Vascular and Lung Pathobiology, which has the goal of drawing trainees in surgery and cardiology into basic laboratory investigation. The rationale for the program is to enhance and ensure the development of basic and clinical investigators who have broadly based knowledge in the major fields related to research in cardiovascular disease. The in-depth background and experience obtained during the training period is intended to allow fellows to embark on careers as independent investigators. There is a clear need for investigators with surgical and cardiology viewpoints to undertake such training, as clinical procedures and patient care are closely tied to advanced in research. The participating faculty is drawn from multiple Departments at the Medical Center. Many participating faculty have long-standing collaborative interactions, as well as strong training records. The training program will include research work in the laboratory of a faculty mentor, selected graduate courses, a tutorial in the research area, and didactic and work-in-progress seminar series, and evaluations by an Advisory Committee. The program includes 27 laboratories divided into four units: (1) Vascular Biology, focussed on vascular cell adaptive responses to hypoxemia or viral infections, and novel vascular receptors; (2) Inflammation- Immug Ut, which will focus on inflammatory and thrombotic mechanisms of tissue injury; (3) Genomics, which has novel genetic causes of obesity and diabetes as the prime areas for investigation; and (4) Cardiobiology, whose members will investigate coupled gating of calcium-release channels, myocardial blood flow and metabolism, ventricular mechanics and cardiac myocyte signalling cascades. Projects are brought together by a common focus on cells in the normal vessel wall, cellular elements which infiltrate in pathologic situations, such as atherosclerosis, as well as the myocardium. Research projects in which trainees will participate concern dissection of the roles of these cells in maintenance of vascular homeostasis and their participation in pathologic events underlying the formation and progression of vascular lesions. Our goal is to draw on the talents and enthusiasm of surgical and cardiology trainees in order to direct their lattention to productive longterm investigative careers.