MOTOR CORTEX AND THALAMOCORTICAL NETWORK IN LOCOMOTION

描述（改编自申请人摘要） 该建议旨在1）了解识别之间的关系 运动皮层网络和运动行为内的元素，以及2） 理解大脑中控制丘脑-皮层关系的机制， 完整的运动系统所有数据将从经过训练的猫中获得 以不同的速度在一个实验室的平面上行走， 上坡和下坡，前肢上绑着重物，克服障碍 走在水平梯子的扁平横梁上。的关系 鉴定的皮质-皮质神经元、离皮质传出神经元和推定的 将在不同的运动行为期间记录中间神经元。在 此外，将记录这些识别的神经元的活动 与丘脑-皮质投射神经元的活动同时， 它们之间的相互作用将使用互相关方法进行分析， 休息”和运动期间。将特别强调阐明 规则的强度和特异性的功能之间的联系， 研究中的丘脑-皮质和皮质神经元的数量。两大 问题将被解决：1）在多大程度上不同的活动， 所识别的运动皮层传出神经元的类别（例如，S1，SII，颈侧， 皮质丘脑、皮质脊髓等）和推定的抑制性中间神经元 在不同条件下的运动能力有何不同为性状 更好地与皮质层、形态细胞类型或 轴突的目的地2)VL的活动模式是什么 丘脑-皮层投射神经元在不同条件下运动过程中的变化 这些模式与皮层神经元的模式相比如何？ VL投射和VL投射之间的突触联系有什么特点 神经元和皮质受体神经元，以及这些联系如何在 不同的运动条件？

DESCRIPTION (adapted from applicant's abstract) This proposal is aimed at 1) understanding the relationship between identified elements within the motor cortical network and locomotion behavior, and 2) understanding the mechanisms governing thalamo-cortical relations in the intact, functioning motor system. All data will be obtained from cats trained to walk inside an experimental chamber on a flat surface at different speeds, uphill and downhill, with weights attached to forelimbs, overcoming obstacles and walking on flat cross-pieces of a horizontal ladder. The relationship of identified cortico-cortical neurons, corticofugal efferent neurons and putative interneurons will be recorded during different locomotion behaviors. In addition, the activity of these identified neurons will be recorded simultaneously with the activity of thalamo-cortical projection neurons, and interactions among them will be analyzed using cross correlation methods at " rest" and during locomotion. Special emphasis will be placed on elucidating rules governing the strength and specificity of functional connections among the population of thalamo-cortical and cortical neurons under study. Two major issues will be addressed: 1) To what extent does the activity of different classes of identified motor cortex efferent neurons (e.g., S1, SII, collosal, corticothalamic, corticospinal, etc) and putative inhibitory interneurons differ in relation to locomotion under different conditions? Are properties better associated with cortical layer, morphological cell type or the destination of the axon? 2) What are the activity patterns of VL thalamo-cortical projection neurons during locomotion under different conditions and how do these patterns compare with those of cortical neurons? What are the characteristics of the synaptic linkages between VL projection neurons and cortical recipient neurons and how do these linkages change under different conditions of locomotion?