VISUAL SYSTEM ORGANIZATION AND DEVELOPMENT

描述：在PI的视觉信息处理工作模式中， 三条分离的平行通路(巨细胞(M)，小细胞(P)， 从外侧膝状体核(LGN)到初级 视皮层(V1)由板层和间隔区(即 V1的细胞色素氧化酶(CO)斑点和斑点间)电路合成 适用于下一步分析的新的输出路径。在这个范围内 方案，V1的独立输出层和车厢具有不同的模式 用于集成来自所有三个输入路径的信号并产生输出 支持纹外区域的信号，专门的而不是特定的 属性，但用于更复杂的可视分析。 根据该模型，该项目的总体目标是测试 这些路径的重要性，定义输入路径如何与 V1层和隔间的电路，并识别所使用的策略 由输出路径支持V1目标区。这项提案的重点是 到视觉区域2(V2)的K和M输入路径和输出路径上， 背侧内侧视区(DM)和颞中视区 (公吨)。具体目标旨在测试由我们的 工作模式。 在目标I中，PI将检查K通路以及该通路和其他通路是如何 整合在V1的CO-BLOB中。在AIM II中，她将决定 LGN K(或M)细胞活动与眼球运动或行为的关系 关联性。在AIM III中，她将定义V1输出的组织 来自CO-BLOB柱的路径。这项拟议研究的结果将 提供重要的新信息，帮助从根本上理解 大脑处理视觉信息和一般的大脑结构。

DESCRIPTION: In the PI's working model of visual information processing, three segregated parallel pathways (magnocellular (M), parvicellular (P), and koniocellular (K)) from the lateral geniculate nucleus (LGN) to primary visual cortex (V1) are utilized by the laminar and compartmental (i.e. cytochrome oxidase (CO) blob and interblob) circuitry of V1 to synthesize new output pathways appropriate for the next steps of analysis. Within this scheme, separate output layers and compartments of V1 have distinct modes for integrating signals from all three input pathways and generating output signals that support extrastriate areas, specialized not for specific attributes, but for more complex visual analysis. In light of this model, the project's broad aims are to test the significance of these pathways, define how input pathways engage the circuitry of V1 layers and compartments, and discern the strategies utilized by the output pathways to support V1 target areas. This proposal focuses on the K and the M input pathways and on output pathways to visual area 2 (V2), the dorsal medial visual area (DM), and the middle temporal visual area (MT). The specific aims are designed to test hypotheses generated by our working model. In Aim I, the PI will examine the K pathway and how this and other pathways are integrated within the CO-blobs of V1. In Aim II, she will determine the relationship of LGN K (or M) cell activity to eye movements or to behavioral relevance. In Aim III she will define the organization of V1 output pathways from CO-blob columns. The results of this proposed studies will contribute important new information to the fundamental understanding of how the brain processes visual information and of brain architecture in general.