SUPERANTIGEN INVOLVEMENT IN PREECLAMPSIA

描述：(改编自《调查员摘要》)：调查员 建议研究一大批妇女，包括怀孕妇女 未进展为子痫前期的高血压者为对照组。 纵向研究将监测T细胞的发生和消失 歪斜。他们将确定超抗原效应的特征是否发生在 先兆子痫：a)初级T细胞的强烈激活；b)MHC类 II依赖的应答；以及c)TCR Vb受限应答，在本例中为Vb4+ T细胞。将通过以下方式启动研究以确定超抗原的来源 用血浆和合体滋养层微绒毛攻击正常T细胞 先兆子痫患者的细胞膜制备及T细胞偏斜监测 在试管中。

DESCRIPTION: (Adapted from the Investigator's Abstract): The investigators propose to study a large group of women, including women with pregnancy-induced hypertension that do not progress to preeclampsia as a control group. Longitudinal studies will monitor the occurrence and disappearance of T-cell skewing. They will determine if the hallmarks of a superantigen effect occur in preeclampsia: a) a robust activation of primary T cells; b) MHC class II-dependent response; and c) a TCR Vb-restricted response, in this case, Vb4+ T-cells. Studies will be initiated to define the source of the superantigen by challenging normal T-cells with plasma and syncytiotrophoblast microvillous membrane preparations from preeclamptic patients and monitoring T-cell skewing in vitro.