CORE--EXPOSURE AND DOSIMETRY MODELING FACILITY

曝光和剂量建模设施核心由 乔治波洛斯医生。为该设施提供服务的工作站和服务器集群 位于EOHSI内，所使用的硬件和软件是设施 EOHSI计算化学动力学实验室(CCL)。 这个核心的目标是调整、改进和测试 (1)估计毒性暴露，包括靶标的药代动力学模型 组织暴露，(2)评估暴露的生物标志物，以及(3)估计 化学品的运输、浓缩和沉积，包括估计 个体间和个体内的差异。提供的支持服务包括 (1)协助数据分析和(2)协助计算机建模。 这一核心过去表现的唯一有形证据包含在 四个例子，下面对其进行批评。 未来的方向是继续努力开发分布式 参数模型，以及将随机效果建模和 创建食物网模型。

The Exposure and Dosimetry Modeling Facility Core is directed by Dr. Georgopoulos. Workstations and server clusters that service this facility are located within the EOHSI and the hardware and software used are facilities of the EOHSI Computational Chemodynamics Laboratory (CCL). The aims of this core are to adapt, improve, and test methods for (1) estimating toxic exposures, including pharmacokinetic modeling of target tissue exposure, (2) assessing biomarkers of exposure, and (3) estimating transport, concentration, and deposition of chemicals, including estimation of inter- and intra-individual variation. The support services offered are (1) assistance with data analysis and (2) assistance with computer modeling. The only tangible evidence of past performance of this Core is contained in four examples, which are critiqued below. Future directions are slated for continued efforts in developing distributed parameter models, and new efforts to incorporate random effects modeling and create food-web models.