Pilot and feasibility studies

P/F计划旨在支持新消化系统的发展 与疾病相关的研究倡议。将提供有限的资金用于：1) 检验可能对消化系统疾病产生影响的新假说 研究，以及2)获得初步数据，以支持未来的应用 校外资金。将为最多四个1-2年的项目提供资金 (第二年资助须经竞争续期)，以及三个类别 调查人员将被考虑：1)没有资金的年轻调查人员(或 持有职业发展奖的调查人员)寻求获得独立 给予支持，2)在其他科学领域有地位的研究人员希望 进入GI研究领域，以及3)目前参与的调查人员 希望寻求新的研究方向的消化系统疾病相关研究 没有得到他们目前拨款的支持。预算限制在每人22,000美元 每年，每个项目，最高总额为88,000美元。应用程序将是 每年向每一位教职员工征集意见(4月，附 一个月后通过电子邮件发送提醒，作为增加申请者的手段 )，并将在DDRCC时事通讯中发布更多公告 DDRCC主页、华盛顿大学校报和 出版了华盛顿大学学术妇女网络(Aawings)。 有前途的博士后研究员，参与胃肠道研究的导师，以及 其他领域的资深调查人员，其专业领域可能是 应用于GI相关研究，将由主任直接联系 这个项目。 提交的项目将由以下成员进行初步审查 执行委员会和内部科学咨询委员会。外面 如果缺少所需的专业知识，将寻求审查员。修订后， 选定的项目将由外部科学专家进行评估并确定优先顺序 由六名来自华盛顿以外的高级调查人员组成的顾问委员会 大学。这些项目将根据以下可能性进行评估 发展成为与GI相关的项目，并将成功竞争 外部资金(例如，NIDDK)。一个适当的机制也是 为审查正在进行的项目和分配第二年的资金而制定。 在为这项申请做准备的过程中，收到了8个P/F项目和 至少由六名内部评审员进行评估。对项目进行了排名 根据他们的平均分数，前四名(Dieckgraefe博士， Simon、Wilson和Heuckeroth)包括在应用程序中。也是 其中包括内部审查员提供的批评意见。前两名 项目(Dieckgraefe博士和Simon博士)得到了种子资金的资助 华盛顿大学医学院院长(威廉·佩克博士)。 如果DDRCC的申请得到资助，Dieckgraefe博士和Simon将 为第二年提供资金(取决于令人满意的进展报告)和 威尔逊博士和希克罗思博士将在第一年获得资助。

The P/F Program aims to support the development of new digestive diseases-related research initiatives. Limited funding will be provided for: 1) testing of novel hypotheses which may have impact on digestive diseases research, and 2) obtaining preliminary data to support future applications for extramural funding. Funds will be provided for up to four 1-2 year projects (with second year funding subject to competitive renewal), and three categories of investigators will be considered: 1) unfunded young investigators (or investigators holding career development awards) seeking to obtain independent grant support, 2) established investigators in other scientific fields who wish to enter the area of GI research, and 3) investigators currently involved in digestive diseases-related research who wish to pursue a new research direction not supported by their current grants. The budget is limited to $22,000 per year, per project, with a maximum total of $88,000. Applications will be solicited from every faculty member on an annual basis (in April, with a reminder sent via e-mail one month later as a means to increase the applicant pool), and additional announcements will be made in the DDRCC newsletter, the DDRCC Home Page, the Washington University Campus Newspaper, and the publication of the Washington University Academic Women's Network (AWNings). Promising postdoctoral fellows, instructors involved in GI research, and established investigators in other fields whose area of expertise could be applied to GI-related research, will be approached directly by the director of the program. Initial review of submitted projects will be carried out by members of the Executive Committee and the Internal Scientific Advisory Board. Outside reviewers will be sought if required expertise is missing. Following revision, selected projects will be evaluated and prioritized by an External Scientific Advisory Board consisting of six senior investigators from outside Washington University. The projects will be evaluated with respect to likelihood of developing into GI-related projects that will successfully compete for extramural (e.g., NIDDK) funding. An appropriate mechanism has also been developed for review of ongoing projects and allocation of second year funding. In preparation for this application, eight P/F projects were received and evaluated by at least six internal reviewers. The projects were ranked according to their averaged scores, and the top four (by Drs. Dieckgraefe, Simon, Wilson, and Heuckeroth) were included with the application. Also included were the critiques provided by the internal reviewers. The top two projects (Drs. Dieckgraefe and Simon) have been funded with seed money provided by the Dean of the Washington University School of Medicine (Dr. William Peck). Should this application for a DDRCC be funded, Drs. Dieckgraefe and Simon will be funded for a second year (subject to a satisfactory progress report) and Drs. Wilson and Heuckeroth will be funded for the first year.