AGE, RISK FACTORS FOR CVD AND COGNITIVE FUNCTIONING

描述（改编自申请人摘要）：心脏衰竭研究 是一项主要的流行病学调查， 心血管疾病发展的危险因素（CVD危险因素） 和CVD危险因素结果（Dawber' 1980; D' Agostino & Kannel，1998）。的 Fragrance研究和其他大型前瞻性研究已经导致了一个 关于CVD风险因素（包括年龄）和CVD影响的广泛文献 结果。相比之下，关于 心血管疾病危险因素对认知功能的影响，可能没有研究表明， 客观衡量的竞争性风险[行为者]对认知的影响 功能 我们将使用来自心脏病研究的心血管危险因素数据（N= 100）。 2，123）在前瞻性设计中，允许我们将CVD风险因素 （包括年龄和性别）两个结果指标：（1）认知水平 （2）10年内认知能力的变化 纵向研究阶段。我们的总体目标是阻止九个最好的 多变量组合的生物和心理社会风险因素， 预测中老年男性认知能力下降， 妇女，并评估年龄，性别和其他生物因素的相对影响， 以及认知功能的心理社会风险因素。

DESCRIPTION (Adapted from the Applicant's Abstract): The Framingham Heart study is a major epidemiological investigation of prospective relationships between risk factors for the development of cardiovascular disease (CVD risk factors) and CVD risk factor outcomes (Dawber' 1980; D'Agostino & Kannel, 1998). The Framingham Study and other large, prospective studies have resulted in an extensive literature on the impact of CVD risk factors (including age) and CVD outcomes. Comparatively, there have been many fewer studies of the impact of CVD risk factors on cognitive functioning, and possibly no studies of the effect of objectively measured, competing risk [actors on cognitive functioning. We will use cardiovascular risk factor data from the Framingham Heart Study (N= 2,123) in a prospective design allowing us to relate CVD risk factors (including age and gender) to two outcome measures: (1) level of cognitive performance and (2) change in cognitive performance over a 10 years longitudinal study period. Our overall goals are to deter nine the best multivariate combination of biological and psychosocial risk factors for the prediction of lowered cognitive ability in middle-aged and elderly men and women, and to evaluate the relative impact of age, gender, and other biological and psychosocial risk factors on cognitive functioning.