Gordon Conference on Glycolipid & Sphingolipid Biology

描述(由申请人提供)：2002年申请部分资助 戈登糖脂和鞘脂生物学研究会议将举行 于1月26日至2月1日在加利福尼亚州文图拉的假日酒店举行。 会议的目的是鼓励思想和信息在 致力于糖脂和糖脂前沿研究的科学家社区 鞘脂研究以及提供一个环境，让调查人员 来自其他科学学科的人可以了解这一点并为之做出贡献 快速发展的领域。鞘磷脂参与了许多生物 过程--如细胞-细胞识别、细胞-底物黏附、免疫 调控、细胞生长和分化，但只是在过去十年里 这些功能的分子基础变得清晰起来，即功能 (糖基)鞘磷脂的两个复杂的头基(作为调节剂) 膜结构、细胞与细胞间的相互作用、受体功能等)和 脂质骨架(神经酰胺、鞘氨醇、1-磷酸鞘氨醇等， 作为第一和第二信使)。此外，这种认识不仅是 不仅能洞察正常的细胞调节，还能洞察 毒素和毒物(包括癌症化学预防和化学治疗 代理人)杀死细胞。这次戈登会议的一个重要方面就是它 汇集了在许多不同学科工作的科学家，例如 基础生物化学、遗传学、发育生物学、癌症化学预防和 化疗、退行性疾病、毒理学和环境健康 科学。由于这种广度(和深度)，戈登会议 糖脂和鞘脂生物学在生物医学中发挥着独特而宝贵的作用 推进这一领域。将寻求广泛的演讲者和参与者 2002年会议，包括本科生和研究生，以及 初级调查员。与本系列中以前的Gordon会议一样，有 将有来自美国以外国家的高比例参与者，因为 以及妇女和少数群体的参与。将鼓励与会者 既参加正式的讲座/讨论，也参加非正式的 在海报演示中。平台会议将涵盖前沿研究 在基础鞘脂生物学(如生物物理学、新陈代谢、细胞内 贩运以及基因组学和基因靶向方法，现代分析 高效液相色谱串联质谱等方法学研究 鞘磷脂在细胞调节中的活体作用，特别是在细胞生长和 细胞凋亡)，并将强调这些新范式和 实验方法正在为疾病的病因、预防和 心理治疗。

DESCRIPTION(provided by applicant): Partial support is requested for the 2002 Gordon Research Conference on Glycolipid and Sphingolipid Biology, to be held at the Holiday Inn, Ventura, CA from January 26 to February 1. The purpose of the conference is to encourage the transfer of ideas and information within the community of scientists who work at the forefront of glycolipid and sphingolipid research as well as to provide an environment where investigators from other scientific disciplines can learn about, and contribute to, this rapidly evolving field. Sphingolipids participate in many biological processes--such as cell-cell recognition, cell-substratum adhesion, immune regulation, cell growth and differentiation, but only in the past decade have the molecular bases for these functions become clear, i.e. that the functions of (glyco)sphingolipids reside in both their complex headgroups (as modulators of membrane structure, cell-cell interactions, receptor functions, etc.) and the lipid backbones (ceramide, sphingosine, sphingosine 1-phosphate and others, as first and second messengers). Furthermore, this understanding is not only giving insight into normal cell regulation, but also, into the pathways whereby toxins and toxicants (including cancer chemopreventive and chemotherapeutic agents) kill cells. An important aspect of this Gordon Conference is that it brings together scientists that work in many different disciplines, such as basic biochemistry, genetics, developmental biology, cancer chemoprevention and chemotherapy, degenerative disorders, toxicology and environmental health sciences. Because of this breadth (and depth), the Gordon Conference on Glycolipid and Sphingolipid Biology plays a unique and valuable role in advancing this field. A broad range of speakers and participants will be sought for the 2002 Conference, including graduate and postgraduate students, and junior investigators. As with previous Gordon Conferences in this series, there will be a high percentage of participants from countries outside the U.S. as well as participation by women and minorities. Conferees will be encouraged to participate both in the formal lecture/discussion sessions, and less formally in poster presentations. The platform sessions will cover leading edge research in basic sphingolipid biology (e.g. biophysics, metabolism, intracellular trafficking as well as genomics and gene targeting approaches, modem analytical methodologies such as HPLC tandem mass spectrometry , and studies of the in vivo roles of sphingolipids in cell regulation, particularly cell growth and apoptosis) and will emphasize the insights that these new paradigms and experimental approaches are providing for disease etiology, prevention and therapy.