High-Resolution 3D Breast Tomograph for Early Cancer De*

描述(由申请人提供)： 此申请是对NCI计划公告编号PAR-01-102的响应 为了证明新的成像技术的可行性和发展 癌症的早期发现、筛查、诊断或影像引导治疗。 该提议的最终目标是开发一种紧凑的层析伽马 用于乳腺癌功能和定量成像的照相机。建议数 摄像头将达到前所未有的空间分辨率，并将与 新型门架系统，可充分适应复杂的断层扫描轨道 采集乳房体积和腋窝区域的样本。基于统计的图像 对采集系统的物理模型进行建模的重建方法 重建复杂轨道将为获取和处理复杂轨道提供极大的灵活性 正在处理系统映像。创新的几何设计将允许 测量绝对定量摄取值并在3D中定位病变 音量。第一阶段的目标将是构建和描述 紧凑型高分辨率伽马相机和层析成像机架及重建 系统。该系统的性能目标是：15厘米x 20厘米的摄像头， 固有分辨率为1.5 mm，光谱分辨率为10%至12%半高宽 140keV伽马射线。乳腺体积成像的最佳扫描轨道 影像检查应在I期临床试验和活检期间确定。 在第二阶段期间将进行指导。

DESCRIPTION (provided by applicant): This application is in response to NCI Program Announcement Number PAR-01-102 for proof of feasibility and development of novel imaging technologies for early detection, screening, diagnosis or image guided treatment of cancer. The ultimate goal of the proposal is to develop a compact, tomographic gamma camera for functional and quantitative imaging of breast cancer. The proposed camera will achieve unprecedented spatial resolution and will be used with a novel gantry system that accommodates complex tomographic orbits to fully sample the breast volume and axillary regions. Statistically based image reconstruction methods that model the physics of the acquisition system and reconstruct complex orbits will provide great flexibility in acquisition and processing system images. The innovative geometrical design will allow measurement of absolute quantitative uptake values and localize lesions in 3D volume. The objective in Phase I will be to construct and characterize the compact high-resolution gamma camera and tomographic gantry and reconstruction system. The performance goals of the system are: a 15 cm x 20 cm camera with intrinsic resolution of 1.5 mm, and a spectral resolution of 10% to 12% FWHM for 140 keV gamma-rays. The optimal tomographic orbits for volumetric breast imaging shall be determined during Phase I. Clinical trials and biopsy guidance will be performed during phase II.