CORE--LABORATORY ANIMALS

描述：（申请人描述）实验动物共享核心 资源继续为癌症中心成员提供动物服务， 折扣率。除了以前提供的服务，我们还增加了一个 治疗和肿瘤评估服务。转基因动物生产 以前列入这一核心的服务现在已经提供， 在转基因/敲除核心中描述。实验室动物核心开始 在1987年的操作，现在包括原来的实验室动物组成部分 加上新的动物模型肿瘤测试和干预服务。核心 目前为88名癌症中心研究人员提供研究动物需求 包括74名利用实验室中心全部核心服务的人员 动物护理在UCHSC校园。核心的总体目标是 促进癌症研究，并为癌症中心的研究人员提供高质量的 为动物实验提供优质、集中和专业的服务， 降低和成本效益的价格。 此共享资源提供以下内容的日常和专门维护 常规的和屏障维持的、无特定病原体（SPF）的啮齿动物， 常规实验室动物和转基因/敲除啮齿动物以及 严重联合免疫缺陷（SCID）和无胸腺，裸鼠和大鼠， 肿瘤的同种异体和异种移植物以及肿瘤检测、生长和干预 问题研究新的疗法可以通过静脉内，腹膜内， 经气管、肿瘤内、基因内或其它途径。样品 收集药代动力学分析用于药理学评价 核心实验动物核心还提供单克隆和多克隆 抗体生产服务、大体和组织病理学、医学摄影 和照片显微镜检查、肿瘤收获和转移、动物模型开发， 准备和操作，动物研究技术培训， 实验动物兽医服务。主要目标是提供状态 高质量的动物维护和癌症研究服务 中心的调查人员是负担得起的和可访问的。

Description: (Applicant's Description) The Laboratory Animal Shared Core Resource continues to provide animal services to Cancer Center members at discounted rates. In addition to services previously provided we have added a treatment and tumor assessment service. The transgenic animal production services which were previously included in this core are now provided and described in the Transgenic/Knockout core. The Laboratory Animal core began operation in 1987, now consists of the original laboratory animal components plus the new animal model tumor testing and intervention service. The core presently serves the research animal needs of 88 Cancer Center investigators including 74 who utilize full core services in the Center for Laboratory Animal Care on the UCHSC campus. The overall objective of the core is to facilitate cancer research and provide Cancer Center investigators with high quality, centralized and specialized services for animal experimentation at reduced and cost effective prices. This shared resource provides routine and specialized maintenance of conventional and barrier- sustained, specific-pathogen-free (SPF) rodents, conventional laboratory animals and transgenic/knockout rodents as well as severe combined immunodeficient (SCID) and athymic, nude mice and rats for allo- and xenografts of tumors and tumor testing, growth and intervention studies. New therapies may be delivered by intravenous, intraperitoneal, transtracheal, intratumoral, intragenic or other routes. Samples for pharmacokinetic analysis are collected for evaluation in the Pharmacology core. The Laboratory Animal core also provides monoclonal and polyclonal antibody production services, gross and histopathology, medical photography and photo microscopy , tumor harvests and transfers, animal model development, preparations and manipulations, training in animal research techniques and laboratory animal veterinary services. The primary goal is to provide state of the art, high quality animal maintenance and research services to Cancer Center investigators that are affordable and accessible.