Core--Trace metals laboratory

微量金属研究支持核心实验室是哥伦比亚大学P30 NIEHS中心的一个既定设施。该实验室使众多研究人员能够精确测量生物标本中的各种金属，包括Pb， As和许多其他金属和金属蛋白。NIEHS中心的预算为仪器、服务合同、方法开发和试点研究分析提供支持，并为实验室主任和实验室经理提供部分支持。在目前的提案中，三个生物医学项目（项目#1、#3和#4）需要对尿液和/或血液样本进行大量的微量金属分析。因此，核心实验室要求供资，以支持与这些服务有关的人员和供应费用的增加。要进行的分析包括血铅分析（项目#1和#4），尿总砷分析（项目#1、#3和#4），以及尿无机砷（InAs）、一甲基胂酸（MMA）和二甲基胂酸（DMA）（项目#3和#4）。在需要时，痕量金属核心实验室将为调查人员提供条形码的无金属尿液和血液收集管。它还将为项目#3和#4中分析的数千份尿液样本提供冷冻储存。

The Trace Metal Research Support Core Laboratory is an established facility in the Columbia University P30 NIEHS Center. The laboratory enables numerous investigators to precisely measure a broad range of metals in biological specimens, including Pb, As, and a host of other metals and metalloproteins. The NIEHS Center budget provides support for instrumentation, service contracts, methods development, and a pilot study analyses, as well as partial support for the laboratory Director and the Laboratory Manager. In the current proposal, three biomedical projects (Projects #1, #3 and #4) require large numbers of trace metal analyses in urine and/or blood samples. Thus, the Core Laboratory requests funding to support the increased personnel and supply costs associated with these services. The analyses to be conducted include blood Pb analyses (Projects #1 and #4), total urinary As analyses (Projects #1, #3 and #4), and urinary inorganic arsenic (InAs), monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) (Projects #3 and #4). Where needed, the Trace Metal Core Laboratory will provide investigators with bar-coded metal-free urine and blood collection tubes. It will also provide for freezer storage of thousands of urine samples to be analyzed in Projects #3 and #4.