HEALTH HAZARDS FROM GROUNDWATER CONTAMINATION

要求提供支持，以继续开展以人类健康为导向的研究，研究超级基金站点中常见的化学品暴露的风险，并研究新的清理技术，以消除接触这些3e站点化学品的可能性。正在调查的污染物包括污染地下水的相对水溶性的化学品，如三氯乙烯，以及环境持久性脂溶性化学品，如多氯联苯和多环芳烃。提出了一个高度整合的、多学科的研究计划，由9个研究项目和4个支持核心单位组成。研究团队由24名研究人员组成，包括9个研究项目和4个支持核心单位的教职员工。由24名研究人员组成的研究团队包括密歇根州立大学(12名)、密歇根大学(8名)、斯坦福大学(2名)、罗格斯大学(1名)和橡树岭国家实验室(1名)的教职员工。这项研究的主要内容包括四个方面：1)了解控制污染物的环境持久性和对参与生物降解的微生物的生物有效性的因素的机制；3)测定故意改变(工程)地下环境对生物降解速度的有效性；4)评价环境产生的化学产品对生物降解速度的影响；4)评价生物修复产生的化学产品的毒性潜力；3)确定故意改变的(工程)地下环境对生物降解速度的有效性；4)评价生物修复产生的化学产品的生物降解率；4)评价生物修复产生的化学产品的毒性潜力。被归类为生物医学的研究项目包括研究多氯联苯对免疫毒性、生殖和发育毒性以及发育神经毒性的影响；场地修复研究包括地下水污染物的再生生物修复；参与化学物质保留的新型大化学物质的合成和开发以参与保留含有卤化溶剂和金属的地下水羽流中的化学物质；以及对控制地下水和土壤生物修复速率的因素的检查。一个核心实验室将协调对多氯联苯和混合废物中常见的其他污染物的生物降解产生的中间产品和最终产品的测试。这项测试将允许修改实验性的补救过程，以最大限度地对环境中发现的有毒混合物进行解毒。博士后培训计划将包括交叉培训经验，以提高新近毕业的博士毕业生在多学科研究团队中表现的能力。外联核心将与密歇根大学环保局危险物质研究中心的社区援助部分合作，编制信息材料，用于与受危险化学品威胁影响的社区合作。

Support is requested to continue human health-oriented research on risks from exposure to chemicals commonly found in Superfund sites and on new clean-up technologies to eliminate the potential for exposure to chemicals from thos3e sites. The pollutants under investigation include relatively water soluble chemicals that contaminate groundwater such as trichloroethylene and environmentally persistent lipid soluble chemicals such as PCBs and PAHs. A highly integrated, multi-disciplinary research program is proposed consisting of nine research projects and four supporting core units. The research team of 24 investigators include faculty at nine research projects and four supporting core units. The research team of 24 investigators include faculty at Michigan State University (12), The University of Michigan (8), Stanford (2), Rutgers (1) ant the Oak Ridge National Laboratory (1). The major thrusts of the research are in four areas: 1) understanding the mechanisms of factors controlling the environmental persistence and bioavailability of contaminants to microbes involved in biodegradation, 3) determination of the effectiveness of purposefully altered (engineered) subsurface environments on the rates of biodegradation and 4) evaluation of chemical products produced from environments on the rates of biodegradation and 4) evaluation of chemical products produced from bioremediation for toxicity potential, 3) determination of the effectiveness of purposefully altered (engineered) subsurface environments on the rates of biodegradation and 4) evaluation of chemical products produced from bioremediation on the rate of biodegradation and 4) evaluation of chemical products produced from bioremediation for toxicity potential. The research projects classified as biomedical include studies examining the effects of PCBs to cause immunotoxicity, reproductive and developmental toxicity, and developmental neurotoxicity, Site remediation research includes reproductive bioremediation of groundwater contaminants, the synthesis and development of novel macrochemical to participate in retention of chemicals to participate in retention of chemicals in groundwater plumes containing halogenated solvents and metals, and an examination of factors that control the rate of groundwater and soil bioremediation. A core laboratory will coordinate the testing of the intermediate and end products generated from biodegradation of PCBs and other contaminants commonly found in mixed waste. This testing will permit modification of experimental remediation processes to maximize the detoxification of toxic mixtures found in the environment. A postdoctoral training program will involve cross training experiences to improve the ability of recent Ph.D. graduates to perform in multi-disciplinary research teams. An Outreach Core will partner with the community assistance component of an EPA Hazardous Substance Research Center at the University of Michigan to produce information materials for use in working with communities impacted by the threat of exposure to hazardous chemicals.