ANIMAL RESOURCE IMPROVEMENT: YNPRC

描述（由申请人提供）： 尽管在开发有效的治疗方法和潜在的候选疫苗方面取得了重大的科学进展，但艾滋病仍然是世界范围内的一个主要医学问题，每年有数百万人新感染和死亡。 艾滋病研究必须继续取得进展，成功地遏制和消除这一全球祸害。 动物模型，特别是那些使用NHP的动物模型，对开发艾滋病的治疗和治愈方法抱有最大的希望。 国家研究资源中心（NCRR）支持的国家灵长类动物研究中心（NPRC）在提供资源开发动物模型以解决这一问题方面发挥着重要作用。 然而，必须提供必要的动物资源和设施基础设施，以支持扩大艾滋病研究和疫苗开发的研究计划，以满足这些关键需求。 这项申请是YNPRC要求翻新和升级现有的动物收容空间，以满足目前和预计的对艾滋病相关研究中使用的更多猕猴的需求。 建议翻新25年前在野外站校园建造的动物饲养空间，这将允许扩大，改善和现代化设施，以满足美国农业部（USDA）法规的所有当前和即将修订的要求。 这些改进将使空间的容量增加260%，从目前的40只动物增加到164只动物。 重要的是，这次翻新将为小群猕猴提供住房，以增加目的繁殖和改善管理。此外，这些改进将在动物区附近增加一个治疗室，用于临床和实验程序。 YNPRC艾滋病和疫苗研究项目的数量和范围的显着增长创造了基础设施改善的需求，以跟上步伐。 目前的首要任务是提供所需的动物设施，以支持恒河猴群体的增长，以满足这些需求。 YNPRC设施的这些改进将大大增强该中心扩大其艾滋病相关研究方案的能力。

DESCRIPTION (provided by applicant): Despite significant scientific advances in the development of effective treatments and potential vaccine candidates, AIDS continues to be a major medical problem world wide, with new infections and deaths in the millions annually. Progress in AIDS research must continue successful in containing and eliminating this global scourge. Animal models, particularly those using NHPs, hold best hope for the development of treatments and cures for AIDS. The National Center for Research Resources (NCRR) supported National Primate Research Centers (NPRC) play a major role in providing resources to develop animal models to address this problems. However, it is essential that the necessary animal resources and facility infrastructure be available to support expanding research programs in AIDS research and vaccine development to address these critical needs. This application is a request by the YNPRC to renovate and upgrade existing animal containment space to meet the current and projected demand for additional macaque monkeys used in AIDS-related research. It is proposed to renovate animal housing space, originally constructed 25 years ago at the Field Station campus, that will allow to expand, improve, and modernize the facility to meet all current and pending revisions to United States Department Agriculture (USDA) regulations. The improvements will increase the capacity of the space by 260 percent, from a current capacity of 40 animals to 164 animals. Importantly, this renovation will provide housing for small groups of macaques to increase purpose breeding and improve management. In addition, the improvements will add a treatment room adjacent to the animal area for both clinical and experimental procedures. The significant growth in the number and scope of AIDS and vaccine research programs at the YNPRC has created demand for infrastructure improvement to keep pace. The top priority now is to provide the animal facilities needed to support the growth of the rhesus monkey colony to meet these needs. These improvements in the facilities of the YNPRC would significantly augment the Center's ability to expand its AIDS-related research program.