FE XAS K EDGE STUDIES OF NON HEME IRON ENZYMES

将使用X射线吸收边和EXAFS光谱来研究 一系列单核分子的电子结构和几何结构 非血红素铁酶。拟研究的系统包括 脂肪氧合酶、苯丙氨酸羟基酶和博莱霉素。《铁人》 并将研究这些酶的铁活性部位，以及 氧被激活，小分子结合形成。一种理解 活性中心的电子结构和几何结构 作为催化过程中涉及的中间体，这些 酶将使我们能够更好地了解 结构与功能实现方式之间的关系 控制住了。

X-ray absorption edge and EXAFS spectroscopy will be used to study the electronic and geometric structure of a series of mononuclear non-heme iron enzymes. The systems to be studied include the lipoxygenases, phenylalanine hydroxylase and bleomycin. The ferrous and ferric active sites of these enzymes will be studied, along with the oxygen activated and small molecule bound forms. An understanding of the electronic and geometric structure of the active sites, as well as the intermediates involved in the catalytic processes, of these enzymes will enable us to gain a better understanding of the relationship between structure and how function is achieved and controlled.