Epigenetic determinants of nephropathy in adults with type 1 diabetes
Epigenetic determinants of nephropathy in adults with type 1 diabetes
批准号:
nhmrc : 1082572
负责人:
Prof Assam El-Osta
金额:
$35.48万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2017-12-31
中文摘要
预防和成功管理糖尿病并发症对澳大利亚人的健康至关重要。我们假设表观遗传途径在一定程度上决定了为什么尽管糖尿病持续时间、治疗强度和平均葡萄糖暴露量相似,但有些糖尿病患者会出现疾病并发症,而另一些患者则不会。
英文摘要
The prevention and successful management of diabetic complications are issues of utmost importance for the health of Australians. We hypothesize that epigenetic pathways partly determine why some individuals with diabetes develop complications of their disease, while others do not, despite a similar duration of diabetes, treatment intensity and mean glucose exposure.
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会议论文
New models of gene regulation in diabetic complications
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批准号:nhmrc : GNT1154650
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项目类别:Research Fellowships
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资助金额:$64.92万
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财政年份:2019
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负责人:Prof Assam El-Osta
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依托单位:
Targeting epigenetic pathways that lead to diabetic complications
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批准号:nhmrc : GNT1142262
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项目类别:Project Grants
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资助金额:$98.99万
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财政年份:2018
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负责人:Prof Assam El-Osta
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依托单位:
Targeting epigenetic pathways that lead to diabetic complications
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批准号:nhmrc : 1142262
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项目类别:Project Grants
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资助金额:$66.93万
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财政年份:2018
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负责人:Prof Assam El-Osta
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依托单位:
The Persisting Vascular Effects of Activation of the Renin-Angiotensin System
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批准号:nhmrc : GNT1102342
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项目类别:Project Grants
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资助金额:$62.85万
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财政年份:2016
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负责人:Prof Assam El-Osta
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依托单位:
Identifying the epigenomic fingerprint of coronary heart disease in Chinese adults with type 2 diabetes
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批准号:nhmrc : 1113188
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项目类别:Targeted Calls
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资助金额:$41.14万
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财政年份:2016
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负责人:Prof Assam El-Osta
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依托单位:
The Persisting Vascular Effects of Activation of the Renin-Angiotensin System
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批准号:nhmrc : 1102342
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项目类别:Project Grants
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资助金额:$43.12万
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财政年份:2016
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负责人:Prof Assam El-Osta
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依托单位:
JDRF/NHMRC Diabetes Complications Centre of Research Excellence
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批准号:nhmrc : GNT1078609
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项目类别:Centres of Research Excellence
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资助金额:$250.0万
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财政年份:2014
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负责人:Prof Assam El-Osta
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依托单位:
JDRF/NHMRC Diabetes Complications Centre of Research Excellence
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批准号:nhmrc : 1078609
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项目类别:Centres of Research Excellence
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资助金额:$173.85万
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财政年份:2014
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负责人:Prof Assam El-Osta
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依托单位:
Development and Epilepsy - Strategies for Innovative Research to improve diagnosis, prevention and treatment in children with difficult to treat Epilepsy
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批准号:nhmrc : 1075563
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项目类别:Targeted Calls
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资助金额:$30.41万
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财政年份:2014
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负责人:Prof Assam El-Osta
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依托单位:
Role of Set7 in diabetes related end-organ injury
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批准号:nhmrc : 1027341
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项目类别:Project Grants
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资助金额:$60.27万
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财政年份:2012
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负责人:Prof Assam El-Osta
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依托单位:
Uncoupled Research Fellowship
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批准号:nhmrc : 526681
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项目类别:NHMRC Research Fellowships
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资助金额:$47.37万
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财政年份:2009
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负责人:Prof Assam El-Osta
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依托单位:
Role of chromatin remodelling in diabetic renal and vascular complications: in vivo studies
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批准号:nhmrc : 526685
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项目类别:NHMRC Project Grants
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资助金额:$31.65万
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财政年份:2009
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负责人:Prof Assam El-Osta
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依托单位:
Functional Significance of MeCP2 Target Genes in the Pathogenesis of Rett Syndrome.
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批准号:nhmrc : 457238
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项目类别:NHMRC Project Grants
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资助金额:$31.79万
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财政年份:2007
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负责人:Prof Assam El-Osta
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依托单位:
The generlaity of the SWI/SNF regulatory complex in mental health and cardiovascular disease
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批准号:nhmrc : 367647
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项目类别:Career Development Fellowships
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资助金额:$18.14万
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财政年份:2006
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负责人:Prof Assam El-Osta
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依托单位:
Role of epigenetic mechanisms in diabetic vascular complications
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批准号:nhmrc : 367621
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项目类别:NHMRC Project Grants
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资助金额:$29.24万
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财政年份:2006
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负责人:Prof Assam El-Osta
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依托单位:
Characterisation of the anti-apoptotic function of P-glycoprotein and transcriptional regulation of the MDR1 gene.
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批准号:nhmrc : 350308
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项目类别:NHMRC Project Grants
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资助金额:$31.31万
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财政年份:2005
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负责人:Prof Assam El-Osta
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依托单位:
A new paradigm for SWI/SNF chromatin function; the ATPase dependent remodeler is a component of the MeCP2 complex
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批准号:nhmrc : 268905
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项目类别:NHMRC Project Grants
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资助金额:$16.95万
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财政年份:2004
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负责人:Prof Assam El-Osta
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依托单位:
Characterisation of the anti-apoptotic function of P-glycoprotein and transcriptional regulation of the MDR1 gene
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批准号:nhmrc : 208930
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项目类别:NHMRC Project Grants
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资助金额:$21.61万
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财政年份:2002
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负责人:Prof Assam El-Osta
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依托单位:
海外基金