SUBSTANCE USE/ABUSE & INTERNALIZING DISORDERS IN YOUTH

描述：(申请人摘要) 申请者要求通过指导职业生涯获得五年的资助 发展奖(KO1)计划，以提高她的方法技能进行 物质(香烟、酒精、 大麻和其他毒品)使用/滥用和内在性障碍(抑郁症 和焦虑)在青年时期。最终目标是获得专业知识 药物使用/滥用与其他精神障碍之间的关系， 特别是内在化的障碍，以及青年的服务需求和使用 同时患有药物滥用和内在性障碍。申请人的 在精神病学流行病学和研究方面有很强的学术培训背景 社会科学方法论，以及她在风险因素方面的研究经验 青少年物质使用、精神卫生服务需求和服务利用 青少年抑郁和影响青少年接受治疗的因素 物质使用的相关问题为这项工作提供了良好的基础。 拟议的培训目标，包括(1)增加关于儿童和儿童的知识 青少年精神病学、药物滥用和依赖；(2)加强 湖南省纵向调查方法及计算机测绘仪器的应用 收集诊断信息；和(3)高级统计培训 专注于共病的纵向数据分析，都将有助于 申请者对创新、全面、技术效率的追求 关于合并症的研究方法。 该奖项的研究计划分为两项研究，相辅相成 建议的培训活动顺序，并提供申请者研究 临床和社区样本方面的经验。在第一项研究中， 200名青少年和一名父母/监护人的临床样本 在管理式医疗研究(1997-1999)中两次接受采访，将重新接受采访 使用计算机化的工具，包括诊断面谈时间表 儿童(DISC-IV)，以评估精神病的患病率和发病年龄 精神障碍，关于发病、频率和物质数量的详细问题 使用、精神障碍家族史和药物使用，以及 其他家族和个人特征。在第二项研究中， 申请者将使用1500个波多黎各的精神评估数据(也是DISC-IV) 来自正在进行的三波社区纵向研究的Rican青年，包括 申请者提供的一套问题，用于研究这一关系 在药物使用/滥用和内化性障碍之间。

DESCRIPTION: (Applicant's Abstract) The applicant is requesting five years of funding through the Mentored Career Development Award (KO1) program to enhance her methodological skills to conduct longitudinal research on the co-occurrence of substance (cigarette, alcohol, marijuana and other drugs) use/abuse and internalizing disorders (depression and anxiety) in youth. The ultimate goal is to gain expertise in the relationship between substance use/abuse and other psychiatric disorders, especially internalizing disorders, and in the service needs and use of youth with comorbid substance abuse and internalizing disorders. The applicant's strong background of academic training in psychiatric epidemiology and research methodology in social sciences, and her research experience on risk factors for adolescent substance use, mental health service need and service use among depressed youth, and factors affecting adolescents receiving treatment for substance use related problems provides an excellent foundation for this work. The proposed training goals, including (1) increased knowledge about child and adolescent psychiatry, substance abuse and dependence; (2) enhanced skills in longitudinal survey methods and use of computerized survey instruments in collecting diagnostic information; and (3) advanced statistical training focusing on longitudinal data analysis of comorbidity, will all facilitate the applicant's pursuit of innovative, comprehensive, technologically efficient approaches in research on comorbidity. The research plan for this Award is divided into two studies which complement the proposed sequence of training activities and provide the applicant research experience with both clinical and community samples. In the first study, a clinical sample of 200 adolescents and one parent/guardian, originally interviewed twice in the Managed Care Study (1997-1999), will be re-interviewed with computerized instruments including the Diagnostic Interview Schedule for Children (DISC-IV), to assess prevalence and age of onset of psychiatric disorders, detailed questions about onset, frequency and quantity of substance use, family history of psychiatric disorders and substance use, as well as other familial and individual characteristics. In the second study, the applicant will use psychiatric assessment data (also DISC-IV) of 1500 Puerto Rican youth from an on-going three-wave community longitudinal study, including a set of questions contributed by the applicant, to study the relationship between substance use/abuse and internalizing disorders.