PTSD and Substance Use/Abuse in Youth

描述（由申请人提供）：此R 01申请是对最近RFA的回应，儿童心理病理学和儿童干预对随后药物滥用的影响，并研究创伤后应激障碍（PTSD）与青少年药物使用/滥用之间的关系。随着9/11恐怖袭击世界贸易中心，随后的恐怖主义威胁和记录的青年PTSD发病率升高，如果我们要为这一人群提供适当的预防和干预，特别是考虑到未来可能发生的恐怖主义袭击，那么了解PTSD和随后的药物使用/滥用之间的关系是很重要的。 拟议的研究是基于对4个现有数据集的二级数据分析，这些数据集包含有关青年创伤后应激障碍和药物使用/滥用的信息。其中两个数据集来自纽约市教育委员会在9/11事件后6个月（6 - 12年级，N=4,690）和18个月（6-12年级，预计N=4,000）进行的两次学校调查。另外两个是社区样本的纵向数据集。社区儿童（CIC，N=717）样本，1975年从纽约北部两个县随机选择平均年龄为5岁的儿童，随访5次，包括年轻人。此外，来自Boricua青年研究的子样本，基线访谈时年龄为10至15岁的人（N= 1，300），每隔12个月重新访谈两次。 本研究将审查：（1）是否有PTSD 9/11之后的创伤后应激障碍（或PTSD症状）与青年中物质使用和滥用的增加有关;（2）青年是否在9/11之后使用物质来自我表达他们的PTSD症状;（3）青年是否暴露于创伤和相关的PTSD（或症状）对后来的物质使用和滥用有影响;（4）PTSD与（或症状）和物质使用/滥用的社会人口因素不同，如性别，种族和家庭SES;以及（5）PTSD（或症状）和物质使用/滥用之间的关系是否可以用其他伴发精神障碍的存在来解释，如重度抑郁和焦虑。希望本项目的研究结果将为临床医生和政策制定者提供有用的信息，以改善创伤后应激障碍和创伤事件后药物使用/滥用青年的服务。

DESCRIPTION (provided by applicant): This R01 application is in response to the recent RFA, the Impact of Child Psychopathology & Childhood Interventions on Subsequent Drug Abuse, and is to study the relationship between Post-traumatic Stress Disorder (PTSD) and substance use/abuse in youth. With the 9/11 terrorist attack on the World Trade Center, subsequent terrorist threats and documented elevated rates of PTSD in youth, it is important to understand the relationship between PTSD and subsequent substance use/abuse, if we are to provide adequate prevention and intervention to this population, particularly in light of possible future terrorist attacks. The proposed study is based on secondary data analysis of 4 existing data sets with information about PTSD and substance use/abuse in youth. Two of the data sets are from two New York City Board of Education School Surveys conducted at 6 months (grades 6 - 12, N=4,690) and 18 months (grades 6-12, projected N=4,000) after 9/11. Two others are longitudinal data sets from community samples. The Children in the Community (CIC, N=717) sample, with children randomly selected from two upstate New York counties in 1975 at mean age of 5, followed-up 5 times, including as young adults. Also, a sub-sample from the Boricua Youth Study, those ages who were 10 to 15 at the baseline interview (N=1,300), and re-interviewed twice at 12 month intervals. This study will examine: (1) whether or not PTSD (or PTSD symptoms) after 9/11 are associated with increased substance use and abuse in youth; (2) whether or not youth use substances to self-medicate their PTSD symptoms after 9/11; (3) whether or not youth exposure to trauma and related PTSD (or symptoms) has an impact on later substance use and abuse; (4) whether or not the relationship between PTSD (or symptoms) and substance use/abuse differ by socio-demographic factors, such as gender, ethnicity, and family SES; and (5) whether or not the relationship between PTSD (or symptoms) and substance use/abuse can be explained by the existence of other comobid psychiatric disorders, such as major depression and anxiety. It is hoped that the findings from this project will provide useful information for clinicians and policy makers, so as to improve service delivery for youth with PTSD and substance use/abuse after traumatic events.