ECOLOGY OF EMERGING ARENAVIRUSES IN SOUTHWESTERN U.S.

描述（改编自申请人的摘要）： 建议的研究是为了提高我们对竞技场流行病学的认识 与美国南部啮齿动物有关的病毒。知识 啮齿动物宿主关系（包括病毒的持续时间和数量） 受感染啮齿动物的散毒）和受感染啮齿动物的地理分布 对准确了解竞技场引起的人类疾病至关重要 病毒最近的研究提供了第一个明确的证据，表明竞技场 病毒在地理上广泛分布于美国南部， 与Neotome属、Peromyscus属和 西格蒙德建议研究的具体目标是：1）扩大我们的 了解地理范围、啮齿动物宿主关系、基因型 与印齿类啮齿动物天然相关的竞技场病毒的多样性 美国南部2)完善我们对白水阿罗约生态的了解 (WWA)和熊峡谷（BCN）病毒; 3）研究WWA的发病机制， BCN病毒在它们的主要啮齿类宿主（Neotoma和Permyscus啮齿类， （4）了解北半球的系统发育史， 美国啮齿动物可以用来准确预测地理范围， 啮齿动物宿主协会的各种地区病毒土著南部 美国;（5）进一步探讨北卡罗来纳州的人类健康意义 美国啮齿动物传播的竞技场病毒。

DESCRIPTION (Adapted from the Applicant's Abstract): The broad objective of the proposed research is to advance our knowledge on the epidemiology of arena viruses associated with rodents native to the southern United States. Knowledge of the rodent host relationship (including duration and magnitude of virus shedding in infected rodents) and geographical distribution of infected rodents is essential to an accurate understanding of the human diseases caused by arena viruses. Recent studies provided the first unequivocal evidence that arena viruses are geographically widely distributed u the southern U.S. in associateion with rodents belonging to the genera Neotome, Peromyscus and Sigmodon. The specific aims of the proposed research are to: 1) Extend our knowledge on the geographic range, rodent host relationship, genotypic diversity off arena viruses naturally associated with signodontine rodents in the southern U.S.; 2) refine our knowledge on the ecology of Whitewater Arroyo (WWA) and Bear Canyon (BCN) viruses; 3) investigate the pathogenesis of WWA and BCN viruses inb their principal rodent hosts (Neotoma and Permyscus rodents, respectively); 4) assess whether knowledge of the phylogenetic history of North American rodents can be used to accurately predict the geographic range and rodent host associations of the various area viruses indigenous to the southern U.S.; and, 5) investigate further the human health significance of North American rodent-borne arena viruses.