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Epigenetic Silencing of Large Chromosomal Regions in Prostate Cancer.

Epigenetic Silencing of Large Chromosomal Regions in Prostate Cancer.
前列腺癌大染色体区域的表观遗传沉默。
批准号:
nhmrc : 481347
负责人:
Prof Susan Clark
金额:
$49.7万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2010-12-31

项目摘要

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中文摘要
翻译
表观遗传学是一个术语,描述了通过涉及DNA化学变化的过程,如甲基化,在不改变DNA序列的情况下对基因表达的修饰。在这项资助中,我们将进一步描述和了解长程表观遗传沉默的机制,并确定其在前列腺癌中的患病率。本研究将为前列腺癌的检测、预后和治疗提供潜在的新靶点。
英文摘要
Epigenetics is a term that desribes modification of gene expression without a change to the DNA sequence through processes that involve chemical change to the DNA such as methylation. In this grant we will further characterise and understand the mechanism involved in long range epigenetic silencing and determine its prevalence in prostate cancer. This study will provide potential novel targets for prostate cancer detection, prognosis and therapy.
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Unravelling The Cancer Epigenome: Mechanisms to Translation
  • 批准号:
    nhmrc : GNT1156408
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $88.83万
  • 财政年份:
    2019
  • 负责人:
    Prof Susan Clark
  • 依托单位:
Epigenomics of Human Disease
  • 批准号:
    nhmrc : GNT1063559
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $82.29万
  • 财政年份:
    2014
  • 负责人:
    Prof Susan Clark
  • 依托单位:
Determining the causes and consequences of epigenetic remodelling in cancer and disease
  • 批准号:
    nhmrc : 1063559
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $57.57万
  • 财政年份:
    2014
  • 负责人:
    Prof Susan Clark
  • 依托单位:
Modelling epigenomic change during early breast carcinogenesis using in vitro and in vivo model systems
  • 批准号:
    nhmrc : 1029579
  • 项目类别:
    Project Grants
  • 资助金额:
    $49.57万
  • 财政年份:
    2012
  • 负责人:
    Prof Susan Clark
  • 依托单位:
海外基金