High-Resolution 3D Breast Tomograph for Early Cancer De*

描述（由申请人提供）： 此申请是响应NCI计划公告编号PAR-01-102 用于证明新成像技术的可行性和开发， 癌症的早期检测、筛查、诊断或图像引导治疗。 该提案的最终目标是开发一种紧凑的断层扫描伽马 用于乳腺癌功能和定量成像的照相机。拟议 相机将实现前所未有的空间分辨率，并将与 新型机架系统，可适应复杂的断层扫描轨道， 对乳房体积和腋窝区域进行采样。统计图像 重建方法，其对采集系统的物理进行建模，以及 重建复杂的轨道将提供极大的采集灵活性， 处理系统图像。创新的几何设计将允许 测量绝对定量摄取值并在3D中定位病变 音量.第一阶段的目标是构建和表征 紧凑型高分辨率伽马照相机和断层扫描机架以及重建 系统该系统的性能目标是：一个15 cm x 20 cm的相机， 固有分辨率为1.5 mm，光谱分辨率为10%至12% FWHM 140千电子伏的伽马射线乳腺容积成像的最佳成像轨道 应在第一阶段确定成像。临床试验和活检 将在第二阶段提供指导。

DESCRIPTION (provided by applicant): This application is in response to NCI Program Announcement Number PAR-01-102 for proof of feasibility and development of novel imaging technologies for early detection, screening, diagnosis or image guided treatment of cancer. The ultimate goal of the proposal is to develop a compact, tomographic gamma camera for functional and quantitative imaging of breast cancer. The proposed camera will achieve unprecedented spatial resolution and will be used with a novel gantry system that accommodates complex tomographic orbits to fully sample the breast volume and axillary regions. Statistically based image reconstruction methods that model the physics of the acquisition system and reconstruct complex orbits will provide great flexibility in acquisition and processing system images. The innovative geometrical design will allow measurement of absolute quantitative uptake values and localize lesions in 3D volume. The objective in Phase I will be to construct and characterize the compact high-resolution gamma camera and tomographic gantry and reconstruction system. The performance goals of the system are: a 15 cm x 20 cm camera with intrinsic resolution of 1.5 mm, and a spectral resolution of 10% to 12% FWHM for 140 keV gamma-rays. The optimal tomographic orbits for volumetric breast imaging shall be determined during Phase I. Clinical trials and biopsy guidance will be performed during phase II.