MR-Guided Coronary Balloon Angioplasty

描述（由申请人提供）：在此竞争延续 应用，我们计划继续专注于磁共振的发展 用于治疗血管疾病的成像装置和方法。常规 介入手术，如球囊血管成形术或血管内支架 主要通过注射造影剂的X射线荧光透视引导 概述了血管腔，但这种方法没有提供有关血管腔的信息 血管壁或其病理。血管内MRI（IVMRI）提供了几种 与其他成像技术相比的显著优点在于，它可以提供 超高分辨率和高对比度清晰度的正常和病变 血管，这对于动脉粥样硬化的表征很重要。我们 已经开发出微型、长、柔性导管线圈和无环导管 用于血管的高分辨率IVMRI的天线。利用这些探测器，我们 成功采集了动脉的体内超高分辨率图像 墙我们的体外研究表明，使用这种方法， 以识别人体动脉的三个形态层并表征 动脉粥样硬化斑块在这项研究中，我们将测试假设， 磁共振引导下冠状动脉球囊成形术可以进行高， 准确性和高速度。为了验证这一假设，我们计划 开发性能最佳的血管内MR探头并修改硬件， 现有MR扫描仪的软件，以便能够控制成像参数， 在血管介入治疗期间，介入医生可以直接进入扫描室。 此外，我们将开发一种实时投影磁共振血管造影技术， 能够通过造影剂直接注射到血管中对血管成像， 动脉我们将测试整个系统的准确性和速度， 人工狭窄的狗模型。我们认为，利用这些新的 方法和设备将开辟一条新的途径， 无辐射冠状动脉介入治疗

DESCRIPTION (Provided by Applicant): In this competing continuation application, we plan to remain focused on the development of magnetic resonance imaging devices and methods for treatment of vascular diseases. Conventional interventional procedures, such as balloon angioplasty or intravascular stent placement, are primarily guided by x-ray fluoroscopy with contrast injections outlining the vascular lumen, but this method provides no information about the vessel wall or its pathology. Intravascular MRI (IVMRI) offers several significant advantages over other imaging techniques, in that it can provide ultra-high resolution with high contrast definition of normal and diseased vessels, which is important for the characterization of atherosclerosis. We have developed miniature, long, flexible catheter coils and loopless catheter antennae for high resolution IVMRI of the blood vessels. Using these probes, we successfully acquired in vivo ultra-high resolution images of the arterial wall. Our in vitro studies demonstrated that, using this method, it is possible to identify the three morphological layers of human arteries and characterize atherosclerotic plaques. In this study, we will test the hypothesis that MR-guided coronary artery balloon angioplasty can be carried out with high accuracy and at high speed. To be able to test this hypothesis, we plan to develop the best-performing intravascular MR probes and modify the hardware and software of existing MR scanners to enable control of the imaging parameters in the scanner room directly by interventionalists during a vascular intervention. Moreover, we will develop a real-time projection MR angiography technique that enables imaging of the blood vessels by contrast injection directly into the arteries. We will test the accuracy and the speed of the overall system on a dog model with an artificial stenosis. We believe that using these novel methods and devices will open up a new avenue for accurate, precise and radiation-free coronary interventions.