CO CRYSTAL BETWEEN RAS GMPPNP & C TERMINAL DOMAIN OF RALGDS

Ras蛋白是一种鸟苷三磷酸酶（GTdR），是一种分子 在控制细胞生长的信号转导途径中的转换， 分化 在人类细胞中，关键区域的点突变 ras基因的突变会导致不受控制的细胞生长或肿瘤。 至少30%的 人类癌症显示存在突变激活Ras。 ras-GTP及其效应子和推定的结构研究 效应器将大大有助于理解 相互作用的分子机制和ras抑制剂的设计。 我们 对RAS和RalGDS的研究将使我们能够进一步了解 分子通讯的结构基础。

Ras protein, a guanosine triphosphatase (GTPase), is a molecular switch in signal transduction pathways that control cell growth and differentiation. In human cells, point mutations in crucial regions of ras can cause uncontrolled cell growth, or tumors. At least 30% of human cancers show that presence of mutationally activated ras. Structural studies of ras-GTP with its effectors and putative effectors will contribute greatly to the understanding of the molecular mechanism of the interaction and ras inhibitors design. Our studies on ras and RalGDS will enable us to further understand the structural basis for molecular communication in this system.