Molecular Imaging: Training for Oncology

描述（由申请人提供）：该计划的目标是培养新一代的研究人员，成为既与生物学和技术的“分子成像”。 术语“分子成像”已经被应用于成像技术，该成像技术联合收割机从两个互补的科学发展中获益，即，1）改进的成像技术导致用于实验室和临床应用的更加通用和高分辨率的成像模式;（二）在癌症生物学的理解方面取得的进展，这些进展被用来为关键分子和相关的生化事件创建成像探针，是肿瘤形成的基础 随着知识的增加，如果这些进展将迅速转化为癌症发现，就需要跨学科的培训。 在纪念斯隆-凯特琳癌症中心（MSKCC），分子成像能力和资源在NCI资助的计划（包括P50体内细胞和分子成像中心（ICMIC）、小动物成像资源计划（SAIRP）和强调癌症多模态生物成像的多肿瘤学指导的PO 1、SPORES和RO 1）的推动下迅速增长。 这种“团队科学”的经验表明，培训需要从两个不同的角度来看：临床研究人员需要更多的分子生物学和实验室成像方法的培训;基础研究人员需要专业成像方法的培训，以及更集中和相关的临床肿瘤学观点。 这个R25 T计划旨在满足这些不同的培训需求。该计划将通过一个内部咨询委员会进行管理，该委员会由具有肿瘤学研究生医学教育经验的临床和基础教师组成。 导师将从NCI支持的癌症研究人员中选出。 将招聘基础和临床实习生，重点是少数民族的平等机会。 专业课程将包括相关的分子生物学，研究方法，先进的成像方法教学，以及基础，转化和临床的个性化研究计划。

DESCRIPTION (provided by applicant): The goal of this program is to train a new generation of researchers, to become facile with both the biology and the technology of "molecular imaging". The term "molecular imaging" has been applied to imaging techniques that combine benefits from 2 complementary scientific developments, namely, 1) the improving technology of imaging leading to ever more versatile and high resolution imaging modalities for both laboratory and clinical applications; 2) advances in understanding of cancer biology which are exploited to create imaging probes for the key molecules and related biochemical events that are fundamental to neoplasia. As knowledge increases, interdisciplinary training will be needed, if these advances are going to be quickly translated into cancer discovery. At Memorial Sloan-Kettering Cancer Center (MSKCC), there has been rapid growth in molecular imaging capabilities and resources fueled by NCI funded initiatives including the P50 In Vivo Cellular and Molecular Imaging Center (ICMIC), the small animal imaging resource program (SAIRP), and multiple oncology directed PO1 's, SPORES, and RO1's that stress the multimodality biologic imaging of cancer. This "team science" experience suggests that training is required from 2 distinct points of perspectives: clinical researchers need more molecular biology and training in laboratory imaging methods; basic researchers need training in specialized imaging methods, and a more focused and relevant clinical oncology perspective. This R25T program is designed to meet these diverse training needs. The program will be managed through an internal advisory committee consisting of clinical and basic faculty with experience in graduate medical education in oncology. Mentors will be drawn from a distinguished group of NCI supported cancer researchers. Both basic and clinical trainees will be recruited, with emphasis on equal opportunities for minorities. A specialized curriculum will include the relevant molecular biology, research methodology, instruction in advanced imaging methods, and an individualized research program of basic, translational and clinical.